个人简历

Current and previous funding
North West Cancer Research (CR947) Functions of mismatch repair proteins in the cellular response to nucleoside analogues. From 01.07.2013
North West Cancer Research Fund (CR675). Role of the XPG homologue Rad13 of fission yeast in nucleotide excision repair, base excision repair and transcription. 01.02.2005-31.05.2008
North West Cancer Research Fund (CR676). Function of the MutS homologue Msh3 in DNA damage tolerance. 01.01.2005-31.12.2007
Swiss National Science Foundation (31-58840.99). Involvement of damage-recognition proteins in repair of mismatched DNA. 01.04.2000-31.05.2003
Teaching
Module organizer MSE-3013 (3rd year research projects)
Lecturer in MSE-2025 (Molecular Biology and Biochemistry)

近期论文

Vejrup-Hansen, R., Fleck, O., Landvad, K., Fahnøe, U., Broendum, S. S., Schreurs, A. S., Kragelund, B. B., Carr, A. M., Holmberg, C. and Nielsen, O. (2014) Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools. J. Cell Sci. 127: 2460-2470.
Fleck, O., Vejrup-Hansen, R., Watson, A., Carr, A. M, Nielsen, O. and Holmberg, C. (2013) Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated. J. Cell Sci. 126: 4985-4994.
Vejrup-Hansen, R., Mizuno, K., Izumi Miyabe, I., Fleck, O., Murray, J. M., Carr, A. M. and Nielsen, O. (2011) Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination. DNA Repair 10: 283-295.
Moss, J., Tinline-Purvis, H., Walker, C. A., Folkes, L. K., Stratford, M. R., Hayles, J., Hoe, K. L., Kim, D. U., Park, H. O., Kearsey, S. E., Fleck, O., Holmberg, C., Olaf Nielsen, O. and Humphrey, T. C. (2010) Break-induced ATR and Ddb1-Cul4Cdt2 ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast. Genes & Dev. 24: 2705-2716.
Nestoras, K., Mohammed, A. H., Schreurs, A. S., Fleck, O., Watson, A. T., Poitelea, M., O'Shea, C., Chahwan, C., Holmberg, C., Kragelund, B. B., Nielsen, O., Osborne, M., Carr, A. M. and Liu, C. (2010) Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms. Genes & Dev. 24:1145-1159.
Tubbs, J. L., Latypov, V., Kanugula, S., Butt, A., Melikishvili, M., Kraehenbuehl, R., Fleck, O., Marriott, A., Watson, A. J., Verbeek, B., McGown, G., Thorncroft, M., Santibanez-Koref, M. F., Millington, C., Arvai, A. S., Kroeger, M. D., Peterson, L. A., Williams, D. M., Fried, M. G., Margison, G. P., Pegg, A. E. and Tainer, J. A. (2009) Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature 459: 808-313.