个人简历

1996-2000 北京大学\t学士\r
2000-2002 香港科技大学\t硕士\r
2002-2009 德克萨斯大学西南医学中心\t博士\r
2009-2010 德克萨斯大学西南医学中心\t博士后\r
2010-2015 宾夕法尼亚大学\t博士后\r
2016-至今 清华大学生命科学学院\t助理教授、副教授

研究领域

相分离现象的普适化调控机制与规律\r
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相分离在自噬、转录调控、表观遗传等领域的生物学意义\r
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基于相分离的技术开发与应用""

近期论文

Xu W#, Pei G#, Liu H#, Ju X, Wang J, Ding Q, Li P*. (2021) Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome. Cell Rep. 36:109482.\r
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Huang X#, Chen S#, Li W, Tang L, Zhang Y, Yang N, Zou Y, Zhai X, Xiao N, Liu W, Li P*, Xu C*. (2021) ROS regulated reversible protein phase separation synchronizes plant flowering. Nat Chem Bio. 17:549-557.\r
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Zuo L, Zhang G, Massett M, Cheng J, Wang L, Gao Y, Li R, Huang X*, Li P*, Qi Z*. (2021) Loci-specific phase separation of FET fusion oncoproteins promotes aberrant gene transcription. Nat Commun. 12:1491.\r
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Zhou M#, Li W#, Li J#, Xie L, Wu R, Wang L, Fu S, Su W, Hu J, Wang J, Li P*. (2020) Phase-separated condensate-aided enrichment of biomolecular interactions for high-throughput drug screening in test tubes. J Biol Chem. 295:11420-11434.\r
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Wang L#, Hu M#, Zuo M, Zhao J, Wu D, Huang L, Wen Y, Li Y, Chen P, Bao X, Dong M, Li G*, Li P*. (2020) Rett syndrome mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin. Cell Res. 30:393-407.\r
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Fang X#, Wang L#, Ishikawa R#, Li Y, Fiedler M, Liu F, Calder G, Rowan B, Weigel D, Li P*, Dean C*. (2019) Arabidopsis FLL2 promotes liquid–liquid phase separation of polyadenylation complexes. Nature. 569:265-269.\r
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Gao Y#, Pei G#, Li D#, Li R, Shao Y, Zhang QC, Li P*. (2019) Multivalent m6A motifs promote phase separation of YTHDF proteins. Cell Res. 29:767-769.\r
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Wang L#, Gao Y#, Zheng X#, Liu C, Dong S, Li R, Zhang G, Wei Y, Qu H, Li Y, Allis CD, Li G, Li H*, Li P*. (2019) Histone modifications regulate chromatin compartmentalization by contributing to a phase separation mechanism. Mol Cell. 76:646-659.\r
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Sun D#, Wu R#, Zheng J, Li P*, Yu L*. (2018) Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation. Cell Res. 28:405-415.\r
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Li P#, Banjade S#, Cheng HC#, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK*. (2012) Phase transitions in the assembly of multivalent signalling proteins. Nature. 483:336-340.