个人简历

研究领域

主要研究高致病性病毒感染和复制、与宿主相互作用过程中的分子机制，以及对病毒生命过程进行调控的手段，并取得了一系列具有影响力的创新成果。""

近期论文

Yan, L. *; Huang, Y. *; Ge, J. *; Liu, Z. *; Lu, P.; Huang, B.; Gao, S.; Wang, J.; Tan, L.; Ye, S.; Yu, F.; Lan, W.; Xu, S.; Zhou, F.; Shi, L.; Guddat, L. W.; Gao, Y. ?; Rao, Z. ?; Lou, Z. ?, A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors.Cell,2022 Nov 10; 185(23):4347-4360. e17\r
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Lou, Z.?; Rao, Z.?, The Life of SARS-CoV-2 Inside Cells: Replication–Transcription Complex Assembly and Function. Annual Review of Biochemistry 2022, 91 (1), 381-401.\r
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Yan, L.*; Yang, Y.*; Li, M.*; Zhang, Y.*; Zheng, L.*; Ge, J.*; Huang, Y. C.*; Liu, Z.*; Wang, T.; Gao, S.; Zhang, R.; Huang, Y. Y.; Guddat, L. W.; Gao, Y.?; Rao, Z.?; Lou, Z.?, Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell 2021, 184 (13), 3474-3485 e11.\r
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Yan, L.*; Ge, J.*; Zheng, L.*; Zhang, Y.; Gao, Y.; Wang, T.; Huang, Y.; Yang, Y.; Gao, S.; Li, M.; Liu, Z.; Wang, H.; Li, Y.; Chen, Y.; Guddat, L. W.; Wang, Q.; Rao, Z.?; Lou, Z.?, Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Cell 2021, 184 (1), 184- 193 e10.\r
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Gao, Y.*; Yan, L.*; Huang, Y.*; Liu, F.*; Zhao, Y.; Cao, L.; Wang, T.; Sun, Q.; Ming, Z.; Zhang, L.; Ge, J.; Zheng, L.; Zhang, Y.; Wang, H.; Zhu, Y.; Zhu, C.; Hu, T.; Hua, T.; Zhang, B.; Yang, X.; Li, J.; Yang, H.; Liu, Z.; Xu, W.; Guddat, L. W.; Wang, Q.?; Lou, Z.?; Rao, Z.?, Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science 2020, 368 (6492), 779-782.\r
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Yan, L.*; Zhang, Y.*; Ge, J.; Zheng, L.; Gao, Y.; Wang, T.; Jia, Z.; Wang, H.; Huang, Y.; Li, M.; Wang, Q.; Rao, Z.?; Lou, Z.?, Architecture of a SARS-CoV-2 mini replication and transcription complex. Nat Commun 2020, 11 (1), 5874.\r
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Zhang, R.*; Cao, L.*; Cui, M.*; Sun, Z.; Hu, M.; Zhang, R.; Stuart, W.; Zhao, X.; Yang, Z.; Li, X.; Sun, Y.; Li, S.; Ding, W.?; Lou, Z.?; Rao, Z., Adeno-associated virus 2 bound to its cellular receptor AAVR. Nat Microbiol 2019, 4 (4), 675-682.