个人简历

于天津大学获学士和硕士学位，2003年毕业于中国海洋大学药物所获博士学位

研究领域

"""""主要从事生化分析检测，以癌症早期诊断为目标，结合纳米技术、传感技术和分子成像技术，建立特异性好、灵敏度高的肿瘤标志物检测新方法。研究方向包括细胞表面糖链的生物学功能及应用研究；功能化纳米材料在生物传感器中的应用；基于信号放大的肿瘤标志物的高灵敏检测以及小分子荧光化合物的合成。实验中将生化分析、纳米材料以及有机合成研究相结合，目的是发展多种灵活有效的新型检测方法实现对肿瘤标志物高灵敏、特异性的检测"

近期论文

Xiaoru Zhang, Ruijuan Li, Yuanyuan Chen, Shusheng Zhang,*Wenshuang Wang, and Fuchuan Li*, Applying DNA rolling circle amplification in fluorescence imaging of cell surface glycans labeled by a metabolic method, Chem. Sci.,2016,7,6182–6189.(IF 9.144)\r
\r
X. R. Zhang, Y. Zhang, F. T. Chen, Y. Li, and S. S. Zhang. Visual detection of single-nucleotide polymorphisms and DNA methyltransferase based on cation-exchange of CuS nanoparticles and click chemistry of functionalized gold nanoparticles, Chem. Commun., 2016, 52, 13261-13264.（IF 6.834）\r
\r
Ying Li, Chuanfeng Yu, Huixia Han, Caisheng Zhao, Xiaoru Zhang*, Sensitive SERS detection of DNA methyltransferase by target triggering primer generation-based multiple signal amplification strategy, Biosensors and Bioelectronics 2016, 81, 111–116. （IF 7.476）\r
\r
Xiaoru Zhang, Hongxia Liu, Ruijuan Li, Ningbo Zhang, Ying Xiong, Shuyan Niu. Chemiluminescence detection of DNA/microRNA based on cation-exchange of CuS nanoparticles and rolling circle amplification, Chem. Commun.,2015,51, 6952-6955 (IF 6.718). （IF 6.834）\r
\r
Wenshuang Wang, Naihan Han, Ruijuan Li, Wenjun Han, Xiaoru Zhang*, Fuchuan Li*, Supercharged Fluorescent Protein as a Versatile Probe for the Detection of Glycosaminoglycansin Vitro andin Vivo, Anal. Chem.2015, 87, 9302−9307(IF 5.636)\r
\r
Xiaoru Zhang, Jiao Chen, Hongxia Liu, Shusheng Zhang. Quartz crystal microbalance detection of protein amplified by nicked circling, rolling circle amplification and biocatalytic precipitation, Biosensors and Bioelectronics 65 (2015) 341–345. (IF 6.451)\r
\r
Xiaoru Zhang, Mingshuai Liu, Yaning Mao, Yunpeng Xu, Shuyan Niu. Ultrasensitive photoelectrochemical immunoassay of antibody against tumor-associated carbohydrate antigen amplified by functionalized graphene derivates and enzymatic biocatalytic precipitation. Biosensors and Bioelectronics 59 (2014) 21–27. (IF 6.451)\r
\r
Xiaoru Zhang, Mingshuai Liu, Hongxia Liu, Shusheng Zhang, Low-toxic Ag2S quantum dots for photoelectrochemical detection glucose and cancer cells. Biosensors and Bioelectronics 56 (2014) 307–312. (IF 6.451)\r
\r
Xiaoru Zhang, Yunpeng Xu, Yanqing Zhao, Weiling Song, A new photoelectrochemical biosensors based on DNA conformational changes and isothermal circular strand-displacement polymerization reaction, Biosensors and Bioelectronics, 2013, 39, 338–341. (IF 6.451).\r
\r
Xiaoru Zhang, Yingshu Guo, Mingshuai Liu and Shusheng Zhang, Photoelectrochemically active species and photoelectrochemical biosensors, RSC Adv., 2013, 3, 2846–2857. (IF 3.708)\r
\r
Xiaoru Zhang, Yunpeng Xu, Yanqiang Yang, Xia Jin, Sujuan Ye, Shusheng Zhang, and Lilin Jiang. New Signal-On Photoelectrochemical Biosensor Based on a Graphene/Quantum-Dot Nanocomposite Amplified by the Dual- Quenched Effect of Bipyridinium Relay and AuNPs，Chem. Eur. J. 2012, 18, 16411 – 16418. (IF 5.696).\r
\r
Xiaoru Zhang, Yanqing Zhao, Huanran Zhou, Bin Qu, A new strategy for photoelectrochemical DNA biosensor using chemiluminescence reaction as light source, Biosensors and Bioelectronics 26 (2011) 2737–2741. (IF 6.451).\r
\r
Xiaoru Zhang, Shuguo Li, Xia Jin, Xuemei Li, Aptamer based photoelectrochemical cytosensor with layer-by-layer assembly of CdSe semiconductor nanoparticles as photoelectrochemically active species, Biosensors and Bioelectronics 26 (2011) 3674–3678. (IF 6.451).\r
\r
Xiaoru Zhang, Shuguo Li, Xia Jin, Shusheng Zhang, A new photoelectrochemical aptasensor for the detection of thrombin based on functionalized graphene and CdSe nanoparticles multilayers, Chem. Commun., 2011, 47, 4929–4931. (IF 6.718).\r
\r
Xiaoru Zhang, Yanqing Zhao, Shuguo Li, Shusheng Zhang, Photoelectrochemical biosensor for detection of adenosine triphosphate in the extracts of cancer cells, Chem. Commun., 2010, 46, 9173–9175. (IF 6.718).\r
\r
Xiaoru Zhang, Ying Li, Haoran Su, Shusheng Zhang, Highly sensitive and selective detection of Hg2+ using mismatched DNA and a molecular light switch complex in aqueous solution. Biosensors and Bioelectronics, 2010, 25(6), 1338-1343. (IF6.451).\r
\r
Xiaoru Zhang, Huanran Zhou, Caifeng Ding, Shusheng Zhang, A dicopper complex chemiluminescence probe for the determination of thiols in the extracts of murine P388 lymphocytic leukemia cell, Chem Commun, 2009, 5624-5626. (IF6.718).\r
\r
Xiaoru Zhang, Haoran Su, Sai Bi, Shuguo Li, Shusheng Zhang, DNA-based amplified electrical bio-barcode assay for one-pot detection of two target DNAs, Biosensors and Bioelectronics, 2009, 24(8), 2730-2734. (IF 6.451).\r
\r
Xiaoru Zhang, Baoping, Qi, Shusheng Zhang, Amplified electrochemical aptasensor for thrombin based on bio-barcode method, Biosensors and Bioelectronics, 2009, 25,259-262. (IF 6.451).\r
\r
Weiling Song，Yawen Luan，Xiaoyan Guo，Peng He，Xiaoru Zhang*，Sensitive detection of DNA methyltransferase using the dendritic rolling circle amplification-induced fluorescence，Analytica Chimica Acta，2017, 956, 57-62. (IF 4.712)\r
\r
Xiaoru Zhang, Fengting Chen, Xiaojie Song, Peng He, Shusheng Zhang, Proximity ligation detection of lectin Concanavalin A and fluorescence imaging cancer cells using carbohydrate functionalized DNA-silver nanocluster probes，Biosensors and Bioelectronics 104 (2018) 27–31. (IF 8.173).\r
\r
Ying Li, Fengting Chen, Zhenzhu Luan, Xiaoru Zhang*, A versatile cathodic “signal-on” photoelectrochemical platform based on a dual-signal amplification strategy, Biosensors and Bioelectronics 119 (2018) 63–69. (IF 8.173).