研究领域

实验室研究方向主要包括以下三个方面：（1）衰老的系统生物学研究、干细胞分化以及癌症的发生发展；（2）开发数据整合和网络分析的计算方法；（3）探求遗传网络中内在的安全稳定机制。运用数据挖掘、统计学方法和网络理论，首先提出合理的生物学假说或模型，然后利用分子生物学、细胞生物学和系统生物学的方法，对该生物学假说或模型进行证实、完善。

近期论文

1) Yaqiang Cao, Guoyu Chen, Gang Wu, Xiaoli Zhang, Joseph McDermott, Xingwei Chen, Chi Xu, Quanlong Jiang, Zhaoxiong Chen, Yingying Zeng, Daosheng Ai, Yi Huang and Jing-Dong J. Han*. Widespread roles of enhancer-like transposable elements in cell identity and long-range genomic interactions. Genome Research. 2018. 29(1):40-52
2) Denghui Liu, Xinyi Wang, Dajian He, Chunli Sun, Xiechao He, Lanzhen Yan, Yizhou Li, Jing-Dong J. Han* and Ping Zheng*. Single cell RNA-sequencing reveals the existence of naïve and primed pluripotency in pre-implantation rhesus monkey embryos. Genome Research. 2018. 10(28):1481-1493
3) Na Sun N, Xiaoming Yu, Fang Li, Denghui Liu, Shengbao Suo S, Weiyang Chen, Shirui Chen, Lu Song, Christopher D. Green CD, Joseph McDermott, Qin Shen, Naihe Jing and Jing-Dong J. Han*, Inference of differentiation time for single cell transcriptomes using cell population reference data, Nature Communications, 2017 Nov 30; 8(1):1856:1-12. doi:10.1038/s41467-017-01860-2
4) Jun Chen, Shengbao Suo, Patrick P. Tam, Jing-Dong J. Han*, Guangdun Peng*, Naihe Jing*. Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nature Protocol, 2017 vol. 12 (3):566-580
5) Guangdun Peng, Shengbao Suo, Jun Chen, Weiyang Chen, Chang Liu, Fang Yu, Ran Wang, Shirui Chen, Na Sun, Guizhong Cui, Lu Song, Patrick P.L. Tam, Jing-Dong J. Han*, Naihe Jing*. Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo. Developmental Cell,2016 Mar21;36(6):681-97.doi:10.1016/ j.devcel
6) Lei Hou, Dan Wang, Di Chen, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, and William B. Mair and Jing-Dong J. Han*. A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metabolism, 2016, 8;23(3):529-40
7) Yi Huang, Xiaoming Yu, Na Sun, Nan Qiao, Yaqiang Cao, Jerome D. Boyd-Kirkup, Qin Shen, and Jing-Dong J Han. Single-cell level spatial gene expression in the embryonic neural differentiation niche. Genome Research. 2015 Apr;25(4):570-81
8) Weiyang Chen, Wei Qian, Gang Wu, Weizhong Chen, Bo Xian, Xingwei Chen, Yaqiang Cao, Christopher D Green, Fanghong Zhao, Kun Tang and Jing-Dong J. Han*, Three-dimensional human facial morphologies as robust aging markers, Cell Research, 2015, 25:574-587 (highlighted by Nature Press Release, Science News, New Scientists, The Guardian, Daily Mail, and NewsWeek, etc)