个人简历
教育背景： 2003年获浙江大学博士学位，美国加州大学圣地亚哥分校（University of California, UCSD）访问学者，美国佐治亚大学（University of Georgia）高级研究学者。 工作经历： 2000年之前在河北省农林科学院等单位工作；2003年10月到北京化工大学工作至今，担任教授和博士生导师。
研究领域
1.代谢工程（Metabolic engineering）：用基因工程法生产大宗或高值化学品，包括3-羟基丙酸、1,3-丙二醇、丙烯酸等C3大宗化合物、新材料聚3-羟基丙酸（P3HP）、抗癌药阿霉素、新型维生素吡咯喹啉醌、医用蛋白等高值药物。 2.合成生物学（Synthetic biology）：以发酵产量为目标的代谢途径耦合强化、基因组编辑(genome editing)、细胞逻辑重构和群体感应（quorum sensing）工程等。 3.应用微生物选育及发酵：包括工业发酵和土壤修复微生物选育，发酵条件优化和智能控制。 4.分离工程（Separation technology）: 微生物发酵及天然产物的高效分离技术。 5.生物农药（Biological pesticide）：天然抗菌活性成分筛选、剂型制备及田间应用。
近期论文
1) High Production of 3-Hydroxypropionic Acid in Klebsiella pneumoniae by Systematic Optimization of Glycerol Metabolism. Scientific Reports, 2016, doi:10.1038/srep26932 (Corresponding author)2) Classifying the DNA assembly protocols for devising cellar architectures. Biotechnology Advances, 2011, 29(1): 156-163 (Corresponding author)3) Evaluation of berberine as a natural compound to inhibit peach brown rot pathogen Monilinia fructicola. Crop Protection, 2017, 91, 20-26 (Corresponding author)4) Development of Red Recombinase System and Antisense RNA Technology in Klebsiella pneumoniae for Production of Chemicals. RSC Advances, 2016, 6, 79920-79927 (Corresponding author)5) 3-Hydroxypropionaldehyde-specific aldehyde dehydrogenase from Bacillus subtilis catalyzes 3-hydroxypropionic acid production in Klebsiella pneumoniae. Biotechnol Lett, 37(3): 717-724, 2015 (Corresponding author)6) Berberine as a natural compound inhibits the development of brown rot fungus Monilinia fructicola, Crop Protection, 2010, 29, 979-984 (Corresponding author)7) NAD+-independent aldehyde oxidase catalyzes cofactor balanced 3-hydroxypropionic acid production in Klebsiella pneumoniae. Biotechnol Lett, 36(11): 2215-2221, 2014 (Corresponding author)8) Enhanced Promoter Activity by Replenishment of Sigma Factor RpoE in Klebsiella pneumoniae. Indian J Microbiol, 2016, 56(2): 190-197 (Corresponding author)9) Contemplating 3-hydroxypropionic acid biosynthesis in Klebsiella pneumoniae. Indian J Microbiol, 2015, 55(2): 131-139 (Corresponding author)10) Distinct promoters affect pyrroloquinoline quinone production in recombinant Escherichia coli and Klebsiella pneumoniae. Curr Microbiol, 69(4): 451-456, 2014 (Corresponding author)11) Insights into 3-hydroxypropionic acid biosynthesis revealed by overexpressing native glycerol dehydrogenase in Klebsiella pneumoniae, Biotechnol Biotec Eq, 28(4): 762–768, 2014 (Corresponding author)12) Enhanced Aldehyde Dehydrogenase Activity by Regenerating NAD+ in Klebsiella pneumoniae and Implications for the Glycerol Dissimilation Pathways. Biotechnol Lett, 35(10): 1609-1615, 2013 (Corresponding author)13) Engineered Constitutive Pathway in Klebsiella pneumoniae for 3-Hydroxypropionic Acid Production and Implications for Decoupling Glycerol Dissimilation Pathways. Curr Microbiol, 66(3): 293-299, 2013 (Corresponding author)14) Gene arrangements in expression vector affect 3-hydroxypropionic acid production in Klebsiella pneumoniae. Indian J Microbiol, 53(4): 418-424, 2013 (Corresponding author)15) Extraction of Cantharidin from Mylabris phalerata Pallas with Compound Enzyme and HPLC Analysis. Asian J Chem, 25(2): 749-751, 2013 (Corresponding author)16) Disease control during peach preservation with a berberine-chitosan composite membrane. Fruits, 67(4): 277-284, 2012 (Corresponding author)17) Heterologous expression of aldehyde dehydrogenase from Saccharomyces cerevisiae in Klebsiella pneumoniae for 3-hydroxypropionic acid production from glycerol. Indian J Microbiol, 52(3): 478-483, 2012 (Corresponding author)18) Successive extraction of glycyrrhizic acid and liquiritin from licorice with cellulase and pectinase, Asian J Chem, 24(10): 4487-4490, 2012 (Corresponding author)19) Simultaneous extraction of polysachharides and isoflavone from semen sojae preparatum and assay for anti-glucoside activity. Asian J Chem, 24(4): 1671-1674, 2011 (Corresponding author)20) Overview of the Rim2/Hipa Superfamily: Structure, Distribution, Transposition and Utilization. Prog Nat Sci, 18(4): 375-379, 2008 (First author)
