个人简历

2012 - date Professor of Pharmaceutical Chemistry and Chemical Biology, Aston University
2009 - 2011 Reader, Division of Integrative and Systems Biology, Institute of Biomedical and Life Sciences
2005 - 2011 Director, RASOR Interdisciplinary Research Collaboration in Proteomic Technologies
2005 - 2011 Director, Doctoral Training Centre in Proteomics
2005 - 2011 Director, Sir Henry Wellcome Functional Genomics Facility
2005 - 2009 Senior Lecturer in Proteomics, Division of Integrative and Systems Biology, Institute of Biomedical and Life Sciences
2002 - 2005 Deputy Director and Head of Proteomics, SHWFGF, University of Glasgow
1993 - 2002 Lecturer, Department of Pure and Applied Chemistry, University of Strathclyde.
1990 - 1993 Research Fellow, St. Catharine's College, Cambridge.
1989 - 1992 Schering Fellow in Bioorganic Chemistry, Department of Chemistry, University of Cambridge.
1988 - 1989 Research Assistant, Oxford University.
1985 - 1988 D.Phil., Biological Chemistry, Oxford University.
1982 - 1985 B.Sc, Chemistry, University of Bristol

近期论文

Verrastro, I, Tveen-Jensen, K, Woscholski, R, Spickett, CM & Pitt, AR 2016, 'Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins' Free Radical Biology and Medicine, vol. 90, pp. 24-34,10.1016/j.freeradbiomed.2015.11.004
Spickett, CM, Verrastro, I & Pitt, AR 2015, 'Uncovering changes in the redox protein interactome of PTEN' Free Radical Biology and Medicine, vol. 86, no. Suppl.1, OP15, pp. S9,10.1016/j.freeradbiomed.2015.07.042
Thakker, A, Spickett, C & Pitt, A 2015, 'Optimisation of chromatographic separation of oxidised phospholipids and detection with targeted approaches provides greater coverage of the oxidised lipidome' Free Radical Biology and Medicine, vol. 86, no. Suppl.1, PP18, pp. S25,10.1016/j.freeradbiomed.2015.07.093
Spickett, CM & Pitt, AR 2015, 'Oxidiative lipidomics coming of age: advances in analysis of oxidized phospholipids in physiology and pathology' Antioxidants and Redox Signaling, vol. 22, no. 18, pp. 1646-1666,10.1089/ars.2014.6098
Spickett, CM & Pitt, AR 2015, ' Oxidative lipidomics coming of age: advances in analysis of oxidized phospholipids in physiology and pathology ' Antioxidants and redox signaling , vol 22, no. 18, pp. 1646-1666., 10.1089/ars.2014.6098
Tveen Jensen, K, Gesellchen, F, Wilson, R, Spickett, C, Cooper, JM & Pitt, A 2015, 'Interfacing low-energy SAW nebulization with liquid chromatography-mass spectrometry for the analysis of biological samples' Scientific Reports, vol. 5, 9736,10.1038/srep09736
Verrastro, I, Pasha, S, Jensen, KT, Pitt, AR & Spickett, CM 2015, 'Mass spectrometry-based methods for identifying oxidized proteins in disease: advances and challenges' Biomolecules, vol. 5, no. 2, pp. 378-411,10.3390/biom5020378
Reis, A, Rudnitskaya, A, Chariyavilaskul, P, Dhaun, N, Melville, V, Goddard, J, Webb, DJ, Pitt, AR & Spickett, CM 2015, 'Top-down lipidomics of low density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease' Journal of Lipid Research, vol. 56, no. 2, pp. 413-422,10.1194/jlr.M055624
Rezende Valim, L, Davies, JA, Tveen Jensen, K, Guo, R, Willison, KR, Spickett, CM, Pitt, AR & Klug, DR 2014, 'Identification and relative quantification of tyrosine nitration in a model peptide using two-dimensional infrared spectroscopy' Journal of Physical Chemistry: Part B, vol. 118, no. 45, pp. 12855-12864,10.1021/jp509053q
Sandison, ME, Tveen Jensen, K, Gesellchen, F, Cooper, JM & Pitt, AR 2014, 'Magnetite-doped polydimethylsiloxane (PDMS) for phosphopeptide enrichment' Analyst, vol. 139, no. 19, pp. 4974-4981,10.1039/C4AN00750F
Tveen-Jensen, K, Reis, A, Spickett, CM & Pitt, AR 2014, 'Targeted mass spectrometry methods for detecting oxidative post-translational modifications' Free Radical Biology and Medicine, vol. 75, no. Suppl.1, P93, pp. S52-S53,10.1016/j.freeradbiomed.2014.10.825
Pasha, S, Tveen Jensen, K, Pitt, AR & Spickett, CM 2014, 'Detection and quantification of protein oxidation in sarcopenic models: a mass spectrometry study' Free Radical Biology and Medicine, vol. 75, no. Suppl.1, P68, pp. S44,10.1016/j.freeradbiomed.2014.10.800
Jiwaji, M, Sandison, ME, Reboud, J, Stevenson, R, Daly, R, Barkess, G, Faulds, K, Kolch, W, Graham, D, Girolami, MA, Cooper, JM & Pitt, A 2014, 'Quantification of functionalised gold nanoparticle-targeted knockdown of gene expression in HeLa cells' PLoS ONE, vol. 9, no. 6, e99458,10.1371/journal.pone.0099458
Maciel, E, Neves, BM, Santinha, D, Reis, A, Domingues, P, Cruz, MT, Pitt, AR, Spickett, CM & Domingues, MRM 2014, 'Detection of phosphatidylserine with a modified polar head group in human keratinocytes exposed to the radical generator AAPH' Archives of Biochemistry and Biophysics, vol. 548, pp. 38–45,10.1016/j.abb.2014.02.002
Robaszkiewicz, A, Bartosz, G, Pitt, AR, Thakker, A, Armstrong, RA, Spickett, CM & Soszynski, M 2014, 'HOCl-modified phosphatidylcholines induce apoptosis and redox imbalance in HUVEC-ST cells' Archives of Biochemistry and Biophysics, vol. 548, pp. 1-10,10.1016/j.abb.2014.02.013
Calimport, S, Pitt, AR & Spickett, CM 2013, 'Residue-specific investigation of the relationship between oxidation and activity of a dual specificity phosphatase by mass spectrometry' Free Radical Biology and Medicine, vol. 65, no. Suppl.2, PSS110, pp. S57,10.1016/j.freeradbiomed.2013.10.527
Tveen Jensen, K, Reis, A, Mouls, L, Pitt, AR & Spickett, CM 2013, 'Reporter ion-based mass spectrometry approaches for the detection of non-enzymatic protein modifications in biological samples' Journal of Proteomics, vol. 92, pp. 71-79,10.1016/j.jprot.2013.03.033
Spickett, CM, Tveen-jensen, K, Reis, A & Pitt, AR 2013, 'Protein modification and phospholipid oxidation' Free Radical Biology and Medicine, vol. 65, no. Suppl.1, pp. S15,10.1016/j.freeradbiomed.2013.08.140
Reis, A, Rudnitskaya, A, Blackburn, GJ, Fauzi, NM, Pitt, AR & Spickett, CM 2013, 'A comparison of five lipid extraction solvent systems for lipidomic studies of human LDL' Journal of Lipid Research, vol. 54, no. 7, pp. 1812-1824,10.1194/jlr.M034330
Spickett, CM, Reis, A & Pitt, AR 2013, 'Use of narrow mass-window, high-resolution extracted product ion chromatograms for the sensitive and selective identification of protein modifications' Analytical Chemistry, vol. 85, no. 9, pp. 4621-4627,10.1021/ac400131f