个人简历

学历:r
哲学博士 (1994) 美国Drexal大学医学院（原宾州医学院）药理系r
医学硕士 (1985) 原苏州医学院药理教研室r
医疗专业 (1980) 原苏州医学院医疗系r
r
主要工作经历:r
2003-至今: 苏州大学药学院药理系系，教授, 博导。r
1999-2003: 哈佛大学医学院附属麻省总医院，讲师，研究员。r
1994-1999: 美国国家卫生研究院，博士后。r
1988-1994: 美国Drexal大学（原宾州医学院）医学院药理系，攻读博士学位。r
1988-1988: 原苏州医学院药理教研室，讲师r
r
荣誉：r
2014：2013年度江苏省科技奖三等奖r
2010：年苏州大学医学部年度突出贡献奖r
2007：苏州市科技进步二等奖r
2007：苏州大学科技进步一等奖r
2007：苏州大学苏鑫奖一等奖r
2006：被收录于第六版美国Marquis名人录(Marquis Who’s Who)。r
2005：苏州大学周氏研究优异奖。r
2004：苏州大学周氏教育优异奖。r
1994: 宾洲医学院研究院Ogburn 优秀博士论文奖。r
1993:宾洲医学院研究院研究生研究成就奖。

研究领域

""""""

近期论文

Wang JD, Cao YL, Li Q, Yang YP, Jin M, Chen D, Wang F, Wang GH, Qin ZH, Hu LF, Liu CF. A pivotal role of c-Fos-mediated BECN1/Beclin 1 expression in dopamine D2-like receptor agonist-induced autophagy activation. Autophagy in press.r
r
Li M, Zhou ZP, Sun M， Cao L, Chen J, Qin YY, Gu JH, Han F, Sheng R, Wu JC, Ding Y, Qin ZH. NADPH, a pentose phosphate pathway product, might be a novel drug candidate for ischemic stroke. 2015; Stroke, in press.r
r
Wu JY, Li M, Cai LJ, Sun ML, Chen D, Ren H,G, Xia Q, Tao ZT, Qin ZH, Hu QS, Wang GH. Protease Omi cleavage Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cels and cerebral injury in MCAO mice. Acta Pharmacologica Sin 2015 36(9):1043-52.r
r
Liu EP, Wang Y, He XH, Guan JJ, Wang J, Qin ZH, Sun WP. Whole blood PCR amplification with pfu DNA polymerase and its application in single-nucleotide polymorphism analysis. Genet Test Mol Biomarkers 2015 Sep 11. [Epub ahead of print].r
r
Xu YL, Kou JQ, Wang SZ, Chen CX, Qin ZH. Neurotoxin from Naja naja atra venom inhibits skin allograft rejection in rats. Int Immunopharmacol. 2015 Set; 26(1):188-98. doi: 10.1016/j.intimp.2015.05.040.r
r
Cao L, Chen J, Li M, Qin YY, Sun M, Sheng R, Han F, Wang G, Qin ZH. The endogenous level of TIGAR in brain is associated with the vulnerability of neurons to ischemic injury. Neurosci Bull 2015 Oct31(5):527-40.r
r
Hou YS, Guan JJ, Xu HD, Wu F, Sheng R, Qin ZH. Sestrin2 protects dopaminergic cells against rotenone toxicity through AMPK-dependent autophagy activation. Mol Cell Biol. 2015 Aug; 35(16): 2740-51.r
r
Yu HP, Xie JM, Li B, Sun YH, Gao QG, Ding ZH, Wu HR, Qin ZH. TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway. Scientific Reports, 2015 Apr 30;5:9853. doi: 10.1038/srep09853.r
r
Zhang XY, Zhang TT, Song DD, Zhou J, Han R, Qin ZH, Sheng R. Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells. Mol Brain. 2015 Mar 26;8(1):20. doi: 10.1186/s13041-015-0112-3.r
r
Chen CX, Chen JY, Kou JQ, Xu YL, Wang SZ, Zhu Q, Yang L, Qin ZH. Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atra. Evid Based Complement Alternat Med. 2015;2015:387094. doi: 10.1155/2015/387094. Epub 2015 Feb 12.r
r
Guan J-J, Zhang X-D, Sun W, Qi L, Wu J-C, Qin Z-H. DRAM1 regulates apoptosis through increasing protein levels andlysosomal localization of BAX. Cell Death & Disease. 2015 Jan 29;6:e1624. doi: 10.1038/cddis.2014.546.r
r
Gao F, Chen D, Si J, Hu Q, Qin Z, Fang M, Wang G. The mitochondrial protein BNP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway. Hum Mol Genet 2015 May 1; 24(9): 2528-38.r
r
Sun M, Li M, Huang Q, Han F, Gu JH, Xie J, Han R, Qin ZH, Zhou Z. Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism. Neurochem Int. 2015 Jan;80:99-109. doi: 10.1016/j.neuint.2014.09.006. Epub 2014 Nov 4.r
r
Wu F, Xu HD, Guan JJ, Hou YS, Gu JH, Zhen XC, Qin ZH. Rotenone impairs autophagic flux and lysosomal functions in Parkinson’s disease. Neurosicence 2015 Jan 22; 284:900-11. doi: 10.1016/j.neuroscience.2014.11.004. Epub 2014 Nov 13.r
r
Cui K, Kou J, Gu JH, Han R, Wang G, Zhen X, Qin ZH. Naja naja atra venom a meliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress. BMC Complementary & Alternative Medicine. 2014 Dec 2;14:461. doi: 10.1186/1472-6882-14-461.r
r
Shen J, Xie Y, Sun ML, Han R, Qin ZH, He JK. Antitumor activity of cobrotoxin in human lung adenocarcinoma A549 cells and following transplantation in nude mice. Oncol Lett. 2014 Nov;8(5):1961-1965. Epub 2014 Aug 21.r
r
Han R, Liang H, Qin ZH, Liu CY. Crotoxin induces apoptosis and autophagy in human lung carcinoma cells in vitro via activation of the p38MAPK signaling pathway. Acta Pharmacol Sin. 2014 Oct;35(10):1323-1332. doi: 10.1038/aps.2014.62. Epub 2014 Aug 18.r
r
Xie JM, Li B, Yu HP, Gao QG, Li W, Wu HR, Qin ZH. TIGAR has a dual role in cancer cell survival through regulating apoptosis and autophagy. Cancer Res. 2014 Sep 15;74(18):5127-38. doi: 10.1158/0008-5472.CAN-13-3517. Epub 2014 Aug 1.r
r
Zhu J*, Kou J *, Wang S, Xu Y, Cui K, Ding Z, Han R, Qin ZH. Naja naja atra Venom Protects Manifestations of Systemic Lupus Erythematosus in MRL/lpr mice. Evidence Based Complementary and Alternative Medicine 2014:969482. doi 10.1158/0008-5472.