个人简历

1987年-1992年：柏林自由大学免疫所 获医学博士学位
1992年-1994年：美国Fox Chase癌症研究中心 博士后
1994年-2000年：德国MDC分子医学中心 课题组长
2000年-2005年：柏林自由大学 终生研究员，于2005年辞职
2005年-今： 中国科学院生物物理研究所

研究领域

肿瘤微环境与肿瘤免疫

近期论文

1) Ji T, Lang J, Wang J, Cai R, Zhang Y, Qi F, Zhang L, Zhao X, Wu W, Hao J, Qin Z*, Zhao Y*, Nie G*. 2017. Designing Liposomes To Suppress Extracellular Matrix Expression To Enhance Drug Penetration and Pancreatic Tumor Therapy. ACS Nano, 11(9):8668-8678.
2) Ni C, Ma P, Qu L, Wu F, Hao J, Wang R, Lu Y, Yang W, Erben U, Qin Z*. 2017. Accelerated tumour metastasis due to interferon-gamma receptor-mediated dissociation of perivascular cells from blood vessels. J Pathol, 242(3):334-346.
3) Deng H, Song K, Zhao X, Li Y, Wang F, Zhang J, Dong A, Qin Z*. 2017. Tumor Microenvironment Activated Membrane Fusogenic Liposome with Speedy Antibody and Doxorubicin Delivery for Synergistic Treatment of Metastatic Tumors. ACS Appl Mater Interfaces, 9(11):9315-9326.
4) Xu X, Meng Q, Erben U, Wang P, Glauben R, Kuhl AA, Wu H, Ma CW, Hu M, Wang Y, Sun W, Jia J, Wu X, Chen W, Siegmund B, Qin Z*. 2017. Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner. Cell Mol Immunol, 14(7):597-606.
5) Shao W, Zhang C, Liu E, Zhang L, Ma J, Zhu Z, Gong X, Qin Z*, Qiu X*. 2016. Identification of Liver Epithelial Cell-derived Ig Expression in mu chain-deficient mice. Sci Rep 6: 23669
6) Atretkhany KS, Nosenko MA, Gogoleva VS, Zvartsev RV, Qin Z, Nedospasov SA, Drutskaya MS*. 2016. TNF Neutralization Results in the Delay of Transplantable Tumor Growth and Reduced MDSC Accumulation. Front Immunol 7: 147
7) Xu X, Meng Q, Erben U, Wang P, Glauben R, Kuhl AA, Wu H, Ma CW, Hu M, Wang Y, Sun W, Jia J, Wu X, Chen W, Siegmund B, Qin Z*. 2016. Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner. Cell Mol Immunol.
8) Chen L, Li J, Wang F, Dai C, Wu F, Liu X, Li T, Glauben R, Zhang Y, Nie G, He Y*, Qin Z*. 2016. Tie2 expression on macrophages is required for blood vessel reconstruction and tumor relapse after chemotherapy. Cancer Res
9) Ji T, Zhao Y, Ding Y, Wang J, Zhao R, Lang J, Qin H, Liu X, Shi J, Tao N, Qin Z, Nie G*. 2016. Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation. Angew Chem Int Ed Engl. 55(3): 1050–1055.
10) Sun L, Sun C, Liang Z, Li H, Chen L, Luo H, Zhang H, Ding P, Sun X, Qin Z*, Zhao Y*. 2015. FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells. Sci Rep 5: 14871
11) Yang S, Wang Y, Mei K, Zhang S, Sun X, Ren F, Liu S, Yang Z, Wang X, Qin Z, Chang Z*. 2015. Tumor necrosis factor receptor 2 (TNFR2).interleukin-17 receptor D (IL-17RD) heteromerization reveals a novel mechanism for NF-kappaB activation. J Biol Chem 290: 861-71
12) Xu M, Liu M, Du X, Li S, Li H, Li X, Li Y, Wang Y, Qin Z, Fu YX*, Wang S*. 2015. Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype. J Immunol 194: 4997-5006
13) Zhang J*, Ni C, Yang Z, Piontek A, Chen H, Wang S, Fan Y, Qin Z, Piontek J. 2015. Specific binding of Clostridium perfringens enterotoxin fragment to Claudin-b and modulation of zebrafish epidermal barrier. Exp Dermatol 24: 605-10
14) Ji T, Ding Y, Zhao Y, Wang J, Qin H, Liu X, Lang J, Zhao R, Zhang Y, Shi J, Tao N, Qin Z*, Nie G*. 2015. Peptide assembly integration of fibroblast-targeting and cell-penetration features for enhanced antitumor drug delivery. Adv Mater 27: 1865-73
15) Chen L, Li J, Zhang J, Dai C, Liu X, Wang J, Gao Z, Guo H, Wang R, Lu S, Wang F, Zhang H, Chen H, Fan X, Wang S, Qin Z*. 2015. S100A4 promotes liver fibrosis via activation of hepatic stellate cells. J Hepatol 62: 156-64
16) Xing S, Luo Y, Liu Z, Bu P, Duan H, Liu D, Wang P, Yang J, Song L, Feng J, Yang D, Qin Z, Yan X*. 2014. Targeting endothelial CD146 attenuates colitis and prevents colitis-associated carcinogenesis. Am J Pathol 184: 1604-16
17) Ni C, Wang C, Zhang J, Qu L, Liu X, Lu Y, Yang W, Deng J, Lorenz D, Gao P, Meng Q, Yan X, Blasig IE, Qin Z*. 2014. Interferon-gamma Safeguards Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis. Am J Pathol 184: 3308-20
18) Hu X, Li B, Li X, Zhao X, Wan L, Lin G, Yu M, Wang J, Jiang X, Feng W, Qin Z, Yin B*, Li Z*. 2014. Transmembrane TNF-alpha promotes suppressive activities of myeloid-derived suppressor cells via TNFR2. J Immunol 192: 1320-31
19) Gao P, Tao N, Ma Q, Fan WX, Ni C, Wang H, Qin ZH*. 2014. DH332, a synthetic beta-carboline alkaloid, inhibits B cell lymphoma growth by activation of the caspase family. Asian Pac J Cancer Prev 15: 3901-6
20) Deng J, Liu X, Rong L, Ni C, Li X, Yang W, Lu Y, Yan X, Qin C, Zhang L, Qin Z*. 2014. IFNgamma-responsiveness of endothelial cells leads to efficient angiostasis in tumours involving down-regulation of Dll4. J Pathol 233: 170-82