个人简历
学习经历 2008 – 2013 贝勒医学院 博士后 2005 – 2008 路易斯安那州立大学 博士后 1998 – 2004 武汉大学生命科学学院 博士 主要工作经历与任职情况： 2018.04 – 至今 武汉大学生命科学学院院长助理 2015.09 – 至今 武汉大学高等研究院兼职研究员 2015.05 – 至今 武汉大学生命科学学院遗传学系主任 2014.03 – 至今 武汉大学生命科学学院，教授，博士生导师
研究领域
维持细胞基因组完整性和稳定性对于细胞正常生长、分化及增殖至关重要。细胞基因组DNA容易受到内源和外源因素的侵害发生损伤甚至断裂。当DNA损伤应答或修复系统存在缺陷时，易导致基因突变、染色体结构或数量发生异常及基因组稳定性失控等系列问题，最终引发细胞发生癌变、死亡。DNA损伤修复与人类发育、免疫、衰老、神经系统功能及癌症的发生发展密切关联。 DNA修复机制在进化过程中较为保守。本实验室以模式生物酿酒酵母及哺乳动物细胞为研究材料，综合利用遗传学、生化与分子生物学、细胞生物学及现代组学技术与方法，围绕DNA断裂修复与基因组稳定性中的重要科学问题开展研究。主要包括以下研究方向： 1. DNA双链断裂修复的调控机制； 2. 细胞应对复制压力的分子基础； 3. 组蛋白表观遗传修饰在DNA修复和基因组稳定性中作用；
近期论文
1. Sihao Zheng, Dan Li, Zhen Lu, Guangxue Liu, Meng Wang, Poyuan Xing, Min Wang, Yang Dong, Xuejie Wang, Jingyao Li, Simin Zhang, Haoyang Peng, Grzegorz Ira, Guohong Li, Xuefeng Chen#. Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks. Nucleic Acids Research, 2018.09 (In press, corresponding author) 2. Shuqi Li,Zhiyun Xu,Jiawei Xu,Linyu Zuo,Chuanhe Yu,Pu Zheng,Haiyun Gan,Xuezheng Wang,Longtu Li,Sushma Sharma,Andrei Chabes,Di Li,Sheng Wang,Sihao Zheng,Jinbao Li,Xuefeng Chen,Yujie Sun,Dongyi Xu,Junhong Han,Kuiming Chan,Zhi Qi,Jianxun Feng,Qing Li. Rtt105 functions as a chaperone for replication protein A to preserve genome stability. The EMBO Journal, 2018,37,e99154 3. Zhen Wang, Qiao-Yun Long, Lin Chen, Jia-Dong Fan, Zhao-Ning Wang, Lian-Yun Li#, Min Wu#, Xuefeng Chen#. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. BBA-Molecular Cell Research, 2017, 1864:2428–2437 (# Co-corresponding author) 4. Xin Zhao,Chengwen Wei,Jingjing Li,Poyuan Xing,Jingyao Li,Sihao Zheng and Xuefeng Chen#. Cell cycle-dependent control of homologous recombination. Acta Biochimica et Biophysica Sinica, 2017, 49(8): 655–668 (Invited review, corresponding author) 5. Xuefeng Chen#, Hengyao Niu, Yang Yu, Jingjing Wang, Shuangyi Zhu, Jianjie Zhou, Alma Papusha, Dandan Cui, Xuewen Pan, Youngho Kwon, Patrick Sun# and Grzegorz Ira#. Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection. Nucleic Acids Research, 2016, 44: 2742-2753 (# Co-corresponding author) 6. Wenchao Huang, Changchun Yu, Jun Hu, Lili Wang, Zhiwu Dan, Wei Zhou, Chunlan He, Yafei Zeng, Guoxin Yao, Jianzhao Qi, Zhihong Zhang, Renshan Zhu, Xuefeng Chen and Yingguo Zhu. Pentatricopeptide-repeat family protein RF6 functions with hexokinase 6 to rescue rice cytoplasmic male sterility. Proc. Natl. Acad. Sci. USA, 2015, 112: 14984–14989 7. Marenda A. Wilson, YoungHo Kwon, Yuanyuan Xu, Woo-Hyun Chung, Peter Chi, Hengyao Niu, Ryan Mayle, Xuefeng Chen, Anna Malkova, Patrick Sung & Grzegorz Ira. Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration. Nature, 2013, 502(7471):393-396 8. Xuefeng Chen, Dandan Cui, Alma Papusha, Xiaotian Zhang, Chia-Dwo Chu, Jiangwu Tang, Kaifu Chen, Xuewen Pan and Grzegorz Ira. The Fun30 ATP-dependent nucleosome remodeler promotes resection of DNA double-strand break ends. Nature, 2012, 489(7417): 576-580 9. Xuefeng Chen, Hengyao Niu, Woo-Hyun Chung, Zhu Zhu, Alma Papusha, Eun Yong Shim, Sang Eun Lee, Patrick Sung and Grzegorz Ira. Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation. Nature Structural & Molecular Biology, 2011, 18(9):1015-1019 10. Xuefeng Chen, Baojin Ding, Danielle LeJeune, Christine Ruggiero, Shisheng Li. Rpb1 sumoylation in response to UV radiation or transcriptional impairment in yeast. PLoS ONE, 2009, 4(4): e5267 11. Danielle LeJeune,Xuefeng Chen,Christine Ruggiero,Shannon Berryhill,Baojin Ding,Shisheng Li. Yeast Elc1 plays an important role in global genomic repair but not in transcription coupled repair. DNA Repair, 2009, 8(1): 40-50 12. Baojin Ding, Christine Ruggiero, Xuefeng Chen, Shisheng Li. Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair in yeast. DNA Repair, 2007, 6(11):1661-1669 13. Xuefeng Chen, Christine Ruggiero, Shisheng Li. Yeast Rpb9 plays an important role in ubiquitylation and degradation of Rpb1 in response to UV induced DNA damage. Molecular and Cellular Biology, 2007, 27: 4617–4625 14. Shisheng Li, Baojing Ding, Christine Ruggiero, Xuefeng Chen and Michael J. Smerdon. The roles of Rad16 and Rad26 in repairing repressed and actively transcribed genes in yeast. DNA Repair, 2007, 6(11):1596-1606 15. Shisheng Li, Xuefeng Chen, Christine Ruggiero, Baojing Ding, and Michael J. Smerdon. Modulation of Rad26- and Rpb9-mediated DNA repair by different promoter elements. Journal of Biological Chemistry, 2006, 281(48): 36643-36651 16. Shisheng Li, Baojing. Ding, Runqiang. Chen, Christine Ruggiero and Xuefeng Chen. Evidence that the transcription elongation function of Rpb9 is involved in transcription-coupled DNA repair in Saccharomyces cerevisiae. Molecular and Cellular Biology, 2006, 26(24): 9430-9441.
