个人简历
Education Experience 1994-2002 Ph. D. Biochemistry University Wisconsin-Madison, WI, USA 2002-2008 Postdoctoral Organic Chemistry ETH-Zürich, CH Professional Experience 2008-2014 Assistant Professor Department of Chemistry, University of Utah 2014- Professor School of Pharmaceutical Science and Technology, Tianjin University
研究领域
The research in the Woycechowsky group focuses on the supramolecular chemistry of proteins. In particular, we are interested in proteins that assemble into symmetrical, closed-shell, polyhedral capsid structures. Protein capsids can act as molecular containers and delivery vehicles for a variety of molecular cargoes, and therefore are useful for bionanotechnological applications, such as drug delivery, catalysis, and materials synthesis. Protein engineering strategies are used to explore and exploit the supramolecular chemistry of protein capsids. This approach is inherently interdisciplinary, utilizing methods from biochemistry, biophysics, molecular biology, organic chemistry, and cell biology. Research projects in our lab fall into three main areas, including 1) capsid self-assembly, 2) molecular encapsulation, and 3) drug delivery.
近期论文
2012 Conversion of a Dodecahedral Protein Capsid into Pentamers via Minimal Point Mutations Chen, Hsiao-Nung; Woycechowsky, Kenneth J. Biochemistry 51 2012 In Vivo Encapsulation of Nucleic Acids Using an Engineered Nonviral Protein Capsid Lilavivat, Seth; Sardar, Debosmita; Jana, Subrata; et al. Journal of the American Chemical Society 134 2012 Reagentless Oxidative Folding of Disulfide-Rich Peptides Catalyzed by an Intramolecular Diselenide Steiner, Andrew M.; Woycechowsky, Kenneth J.; Olivera, Baldomero M.; et al. Angewandte Chemie-International Edition 51 2011 Directed Evolution of a Protein Container Woersdoerfer, Bigna; Woycechowsky, Kenneth J.; Hilvert, Donald Science 331 2010 Diselenides as universal oxidative folding catalysts of diverse proteins Beld, Joris; Woycechowsky, Kenneth J.; Hilvert, Donald Journal of Biotechnology 150 2010 Small-Molecule Diselenides Catalyze Oxidative Protein Folding in Vivo Beld, Joris; Woycechowsky, Kenneth J.; Hilvert, Donald Acs Chemical Biology 5 2009 Selenoglutathione: Efficient Oxidative Protein Folding by a Diselenide (vol 46, pg 5382, 2007) Beld, Joris; Woycechowsky, Kenneth J.; Hilvert, Donald Biochemistry 48 2008 Catalysis of oxidative protein folding by small-molecule diselenides Beld, Joris; Woycechowsky, Kenneth J.; Hilvert, Donald Biochemistry 47 2008 Relative Tolerance of an Enzymatic Molten Globule and Its Thermostable Counterpart to Point Mutation Woycechowsky, Kenneth J.; Choutko, Alexandra; Vamvaca, Katherina; et al. Biochemistry 47 2007 Minimalist active-site redesign: Teaching old enzymes new tricks Toscano, Miguel D.; Woycechowsky, Kenneth J.; Hilvert, Donald Angewandte Chemie-International Edition 46 2007 Novel enzymes through design and evolution. Woycechowsky, Kenneth J; Vamvaca, Katherina; Hilvert, Donald Advances in enzymology and related areas of molecular biology 75 2007 Selenoglutathione: Efficient oxidative protein folding by a diselenide Beld, Joris; Woycechowsky, Kenneth J.; Hilvert, Donald Biochemistry 46 2006 A simple tagging system for protein encapsulation Seebeck, FP; Woycechowsky, KJ; Zhuang, W; et al. Journal of the American Chemical Society 128 2006 Tunnel plasticity and quaternary structural integrity of a pentameric protein ring Woycechowsky, KJ; Seebeck, FP; Hilvert, D Protein Science 15 2004 Deciphering enzymes - Genetic selection as a probe of structure and mechanism Woycechowsky, KJ; Hilvert, D European Journal of Biochemistry 271 2004 Recombination of fragmented proteins Woycechowsky, KJ Chemistry & Biology 11 2003 Catalysis of protein folding by an immobilized small-molecule dithiol Woycechowsky, KJ; Hook, BA; Raines, RT Biotechnology Progress 19 2003 The CXC motif: A functional mimic of protein disulfide isomerase Woycechowsky, KJ; Raines, RT Biochemistry 42 2000 A highly active immobilized ribonuclease Sweeney, RY; Kelemen, BR; Woycechowsky, KJ; et al. Analytical Biochemistry 286 2000 Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A Klink, TA; Woycechowsky, KJ; Taylor, KM; et al. European Journal of Biochemistry 267
