个人简历
Education Experience 1987-1991 Bachelor of Science Physics Peking University 1993-1996 M.S. Biophysics Tsinghua University 1997-2004 Ph. D. Biophysics University of Virginia 2004-2005 Postdoctoral Pharmacology University of Virginia 2005-2014 Postdoctoral Structural Biology Harvard Medical School Professional Experience 1991-1991 Teaching Assistant Tianjin Sino-German Vocational Institute of Technology 1996-1997 Research Assistant Tsinghua University 2014-2016 Professer Tianjin University
研究领域
We are interested in the structural and mechanistic basis of developmental signaling that are important in stem cell biology, cancer metastasis, and regenerative medicine. At structural levels, we want to understand: how developmental signaling molecules are regulated by extracellular micro-environment, how these molecules are recognized by cell surface receptors, and how these molecules are engaged with intracellular signaling cascades through lipid bilayer. At functional levels, we focus on understanding how ligand isoforms are distinguished by their targeted cells to generate distinct cellular outcomes, and how developmental signaling is involved in stem cell self-renewal and differentiation. Eventually, we want to explore potentials in therapeutic development against cancer and other human diseases.
近期论文
1997 Interaction of rabbit C-reactive protein with phospholipid monolayers studied by microfluorescence film balance with an externally applied electric field. Mi, L Z; Wang, H W; Sui, S F Biophysical journal 73 2015 Structure of bone morphogenetic protein 9 procomplex Mi, Li-Zhi; Brown, Christopher T.; Gao, Yijie; et al. Proceedings of the National Academy of Sciences of the United States of America 112 2015 Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13 Deforche, L.; Roose, E.; Vandenbulcke, A.; et al. Journal of Thrombosis and Haemostasis 13 2017 Expression and purification of functional PDGF receptor beta Shang, Qingbin; Zhao, Liang; Wang, Xiaojing; et al. Biochemical and Biophysical Research Communications 489 2017 A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro Wang, Deping; Chen, Cheng; Liu, Shengnan; et al. Scientific Reports 7 2008 Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs Mi, Li-Zhi; Grey, Michael J.; Nishida, Noritaka; et al. Biochemistry 47 2010 Structure of an integrin with an alpha I domain, complement receptor type 4 Xie, Can; Zhu, Jianghai; Chen, Xing; et al. Embo Journal 29 2010 Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor Lu, Chafen; Mi, Li-Zhi; Grey, Michael J.; et al. Molecular and Cellular Biology 30 2011 Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor Mi, Li-Zhi; Lu, Chafen; Li, Zongli; et al. Nature Structural & Molecular Biology 18 2011 Latent TGF-beta structure and activation Shi, Minlong; Zhu, Jianghai; Wang, Rui; et al. Nature 474 2012 Unexpected fold in the circumsporozoite protein target of malaria vaccines Doud, Michael B.; Koksal, Adem C.; Mi, Li-Zhi; et al. Proceedings of the National Academy of Sciences of the United States of America 109 2012 Molecular basis for complement recognition by integrin alpha(X)beta(2) Chen, Xing; Yu, Yamei; Mi, Li-Zhi; et al. Proceedings of the National Academy of Sciences of the United States of America 109 2012 Structural specializations of alpha(4)beta(7), an integrin that mediates rolling adhesion Yu, Yamei; Zhu, Jianghai; Mi, Li-Zhi; et al. Journal of Cell Biology 196 2012 alpha(v)beta(3) Integrin Crystal Structures and Their Functional Implications Dong, Xianchi; Mi, Li-Zhi; Zhu, Jianghai; et al. Biochemistry 51 2012 Mechanisms for Kinase-mediated Dimerization of the Epidermal Growth Factor Receptor Lu, Chafen; Mi, Li-Zhi; Schuerpf, Thomas; et al. Journal of Biological Chemistry 287
