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Antilla, Jon
2023-05-13 10:42
  • Antilla, Jon
  • Antilla, Jon - Professor-天津大学-药物科学与技术学院-个人资料

近期热点

资料介绍

个人简历


Education Experience 2000 Ph. D. University of Chicago 1995 M.S. Northern Michigan University Professional Experience 2003-2005 Associate Professor The University of Mississippi 2005-2015 Associate professor The University of South Florida 2015- Professor The University of South Florida 2016-2019 Tianjin University, 2020- Zhejiang Sci-tech University

研究领域


""Our group’s focus has been mainly in the development of new catalytic methodology for organic synthesis. Our group is a recognized leader in the area of asymmetric organocatalysis with chiral phosphoric acids. Our methodology in the formation of aminals, in the reduction of imines, desymmetrization of meso-aziridines, and pinnacol rearrangement, for example, have been highly cited extensively (3,679 citations and H-index of 26). Our methods have used in the synthesis of biologically important targets by others, for example: Benjamin List (JACS, 2008, 15786) and Scott Snyder (Angew. Chem. Int. Ed., 2012, 51, 4080. Our aim has been to develop catalytic variants of existing, important reactions, to offer stereochemical control (regioselective, diastereoselective, or enantioselective) and higher efficiency, thus lower the potential costs to make drug targets. As a result we have been considered one of the leading groups in organocatalysis, especially in chiral phosphoric acid based catalysis. Our work has been recognized with a USA National Science Foundation CAREER award, a Thieme Journal Award, and also I was awarded with a JSPS Fellowship to Japan, a great honor. Additionally, part of our work has been to seek “green” alternatives to existing methods, as the use of organocatalysis avoids the employment of potentially toxic metals in an environmentally benign manner.""""

近期论文


“Direct Synthesis of Chiral 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazines via a Catalytic Asymmetric Intramolecular Aza-Friedel–Crafts Reaction,” He, Y.; Lin, M.; Li, Z.; Liang, X.; Li, G.; Antilla, J. C., Org. Lett. 2011, 13, 4490. “Enantioselective Construction of Pyrroloindolines Catalyzed by Chiral Phosphoric Acids: Total Synthesis of (-)- Debromoflustramine B,” Zhang, Z.; Antilla, J. C., Angew. Chem. Int. Ed. 2012, 51, 11778. “Origins of Stereoselectivities in Chiral Phosphoric Acid Catalyzed Allylborations and Propargylations of Aldehydes,” Wang, H.; Jain, P.,; Antilla, J. C.; Houk, K. N. The Journal of Organic Chemistry 2013, 78, 1208. “An Asymmetric Diels-Alder Reaction Catalyzed by Chiral Phosphate Magnesium Complexes: Highly Enantioselective Synthesis of Chiral Spirooxindoles,” Li, G.; Liang, T.; Wojtas, L.; Antilla, J. C., Angew. Chem. Int. Ed. 2013, 52, 4628. “Palladium-Catalyzed Tunable Functionalization of Allylic Imidates: Regioselective Aminoacetoxylation and Aziridination,” Cui, S.; Wojtas, L.; Antilla, J. C. Angew. Chem. Int. Ed. 2011, 50, 8927. \

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