个人简历

丁实，男，1986年6月出生，博士，副教授。2009年毕业于华中科技大学，获得药学学士学位；2015年毕业于中国科学院大学上海药物研究所，获得药物化学博士学位。2016年4月起开始在辽宁大学从事教学和科研的工作，担任讲师的职务

研究领域

1. 基于靶点的新药开发：如新型EGFR激酶抑制剂类抗肿瘤药物、LpxC抑制剂类抗革兰氏阴性菌药物、凝血因子Xa抑制剂类抗凝血药物的设计、合成及构效关系研究
2. 天然产物的全合成及结构修饰
3. 药物的制备工艺优化

近期论文

1. Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents. Bioorganic & Medicinal Chemistry Letters,2018, 28(2): 94~102. (第一作者)
2. Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents.Bioorganic & Medicinal Chemistry Letters,2015, 25(10): 2203~2210. (第一作者)
3. Design, synthesis and biological evaluation of LpxC inhibitors with novel hydrophilic terminus. Chinese Chemical Letters,2015, 26 (6): 763~767. (第一作者)
4. Design, Synthesis, and Structure-Activity and Structure-Pharmacokinetic Relationship Studies of Novel [6,6,5] Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor.Journal of Medicinal Chemistry,2014, 57(18): 7770~7791.(第一作者)
5. Synthesis, crystal structure and antitumour activity of ethyl 2-[(2-amino-3cyano-4-phenethyl-4H-naphtho[1,2-b]pyran-8-yl)oxy]acetate.Journal of Chemical Research,2018, 42: 486~489.
6. Synthesis, crystal structure and antitumour activity of 3-amino-N-(5-fluoro-2- methylphenyl)-4-morpholino-1H-indazole-1-carboxamide. Journal of Chemical Research,2017, 41(11): 624~626.
7. Synthesis of new substituted 5-amino-8H-phthalazino[1,2-b] quinazolin-8-one derivatives. Journal of Chemical Research, 2017, 41 (1):18~20.
8. Design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates.Bioorganic & Medicinal Chemistry Letters,2012, 22(2): 814~819.
9. First Scale-Up Synthesis of FU-23, a Novel Water-Soluble Pleuromutilin-Derived Antibiotic.Organic Process Research & Development,2010, 14(4): 815~819.