个人简历

工作经历\r
2020.10 - 至今 哈尔滨工业大学 (深圳)，副教授\r
2018.10 - 2020.09 英国布里斯托大学，博士后（导师：Prof. Varinder Aggarwal）\r
2017.11 - 2018.09 德国亚琛工业大学，博士后（导师：Prof. Magnus Rueping）\r
\r
教育经历\r
2013.10 - 2017.11 德国亚琛工业大学，博士（导师：Prof. Magnus Rueping）\r
2011.09 - 2013.07 哈尔滨工业大学，硕士（导师：夏吾炯 教授）\r
2007.09 - 2011.07 南开大学，本科

研究领域

"""""1) 基于电催化的新型碳碳键和碳杂键的成键反应研究；2) 新型有机光化学反应方法学研究；3) 生物活性分子、药物中间体和天然产物的高效合成"

近期论文

Iron-Catalyzed C(sp3)–H Borylation, Thiolation and Sulfinylation Enabled by Photoinduced Ligand-to-Metal Charge Transfer J.-L. Tu, A.-M. Hu, L. Guo* and W. Xia* J. Am. Chem. Soc. 2023, doi: 10.1021/jacs.3c01082\r
\r
Visible Light Induced Trifluoromethylsulfonylation Reaction of Diazo Compounds Enabled by Manganese Catalysis J. Bai, S. Li, D. Li, Z. Song, B. Li, L. Guo,* L. Song* and W. Xia* Org. Lett. 2023, doi: 10.1021/acs.orglett.3c00490\r
\r
Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts H. Gao, L. Guo, Y. Zhu, C. Yang* and W. Xia* Chem. Commun. 2023, 59, 2771\r
\r
Photoinduced Synthesis of Functionalized Oxacyclic Spirooxindoles via Ring Expansion D. Qi, J. Bai, Z. Song, B. Li, C. Yang, L. Guo* and W. Xia* Org. Lett. 2023, 25, 506\r
\r
Electrochemical synthesis of oxazoles via a phosphine-mediated deoxygenative [3 + 2] cycloaddition of carboxylic acids X. Zhang, Q. Yuan, H. Zhang, Z.-J. Shen, L. Zhao, C. Yang,* L. Guo* and W. Xia* Green Chem. 2023, 25, 1435\r
\r
Electrochemical Synthesis of trans-Olefins from Buta-1,3-dienes and Alkyl Halides H. Zhang, L. Guo, C. Yang* and W. Xia* Synthesis 2023, doi: 10.1055/a-2006-1285\r
\r
Organoboron Reagent-Controlled Selective (Deutero)Hydrodefluorination Z.-J. Shen,# C. Zhu,# X. Zhang, C. Yang, M. Rueping,* L. Guo* and W. Xia* Angew. Chem. Int. Ed. 2023, 62, e202217244\r
\r
Four-Component Synthesis of Spiro-Imidazolidines Enabled by Carbon Nitride Photocatalysis J. Tian, L. Zhao, C. Yang, C. Yang, L. Guo* and W. Xia* ACS Catal. 2023, 13, 866\r
\r
Nickel-Catalyzed Reductive Dicarbofunctionalization of Vinylarenes Enabled by Electrochemical Process P. Hu, L. Guo, L. Zhao, C. Yang* and W. Xia* Org. Lett. 2022, 24, 7583\r
\r
Photo-induced decarboxylative hydroacylation of α-oxocarboxylic acids with terminal alkynes by radical addition–translocation–cyclization in water W. Shi, C. Yang, L. Guo* and W. Xia* Org. Chem. Front. 2022, 9, 6513\r
\r
Synthesis of α-Hydroxy and α-Alkoxy Esters Enabled by a Visible-Light-Induced O–H Insertion Reaction of Diazo Compounds J. Bai, D. Qi, Z. Song, B. Li, L. Guo, C. Yang* and W. Xia* Synlett 2022, 33, 2048\r
\r
Photoinduced Remote C(sp3)-H Cyanation and Oxidation Enabled by a Vinyl Radical-Mediated 1,5-HAT Strategy M. Luo, S. Zhu, C. Shi, Y. Du, C. Yang, L. Guo* and W. Xia* Org. Lett. 2022, 24, 6560\r
\r
Iron-catalyzed ring-opening of cyclic carboxylic acids enabled by photoinduced ligand-to-metal charge transfer J.-L. Tu, H. Gao, M. Luo, L. Zhao, C. Yang, L. Guo* and W. Xia* Green Chem. 2022, 24, 5553\r
\r
Electrochemical Synthesis of β-Functionalized Ketones via Ring-Opening of Cycloalkanols L. Zhao, Q. Zhong, J. Tian, M. Luo, C. Yang, L. Guo* and W. Xia* Org. Lett. 2022, 24, 4421\r
\r
Highly Diastereoselective Synthesis of γ-Lactams Enabled by Photoinduced Deaminative [3 + 2] Annulation Reaction C. Shi, L. Guo, H. Gao, M. Luo, C. Yang* and W. Xia* Org. Lett. 2022, 24, 4365\r
\r
Photoinduced synthesis of functionalized oxetanes via diradical-mediated ring contraction D. Qi, J. Bai, H. Zhang, B. Li, Z. Song, N. Ma, L. Guo,* L. Song* and W. Xia* Green Chem. 2022, 24, 5046\r
\r
Transition Metal-Free Radical α-Oxy C-H Cyclobutylation via Photoinduced Hydrogen Atom Transfer H. Gao, L. Guo, C. Shi, Y. Zhu, C. Yang* and W. Xia* Adv. Synth. Catal. 2022, 364, 2140\r
\r
Electrochemical Reduction of Aldehydes and Ketones for the Synthesis of Alcohols and Diols under Ambient Conditions L. Wang, X. Zhang, R. Y. Xia, C. Yang*, L. Guo* and W. Xia Synlett 2022, 33, 1302\r
\r
Nickel-Catalyzed Reductive Acylation of Carboxylic Acids with Alkyl Halides and N-Hydroxyphthalimide Esters Enabled by Electrochemical Process X. Zhou, L. Guo, H. Zhang, R. Y. Xia, C. Yang* and W. Xia* Adv. Synth. Catal. 2022, 364, 1526\r
\r
Cascade cyclization for the synthesis of indolo [2,1-α]isoquinoline derivatives via visible-lightinduced halogen-atom-transfer (XAT) and hydrogen-atom-transfer (HAT) N. Ma, L. Guo, Z.-J. Shen, D. Qi, C. Yang* and W. Xia* Org. Biomol. Chem. 2022, 20, 1731\r
\r
Electrochemical Synthesis of Functionalized Gem-Difluoroalkenes with Diverse Alkyl Sources via A Defluorinative Alkylation Process H. Zhang, M. Liang, X. Zhang, M.-K. He, C. Yang, L. Guo* and W. Xia* Org. Chem. Front. 2022, 9, 95\r
\r
Conformationally Controlled Linear and Helical Hydrocarbons Bearing Extended Side Chains L. Guo, O. J. Dutton, M. Kucukdisli, M. Davy, O. Wagnieres, C. P. Butts,* E. L. Myers* and V. K. Aggarwal* J. Am. Chem. Soc. 2021, 143, 16682\r
\r
Visible-Light-Induced Multicomponent Synthesis of γ-Amino Esters with Diazo Compounds N. Ma, L. Guo, D. Qi, F. Gao, C. Yang* and W. Xia* Org. Lett. 2021, 23, 6278\r
\r
Multicomponent Synthesis of α-Branched Tertiary and Secondary Amines by Photocatalytic Hydrogen Atom Transfer Strategy X.-K. Qi, L. Guo, L.-J. Yao, H. G., C. Yang* and W. Xia* Org. Lett. 2021, 23, 4473\r
\r
Reductive Arylation of Aliphatic and Aromatic Aldehydes with Cyanoarenes by Electrolysis for the Synthesis of Alcohols X. Zhang, C. Yang,* H. Gao, L. Wang, L. Guo and W. Xia* Org. Lett. 2021, 23, 3472\r
\r
A Facile and Versatile Electro-Reductive System for Hydrodefunctionalization under Ambient Conditions B. Huang, L. Guo* and W. Xia* Green Chem. 2021, 23, 2095\r
\r
Transition Metal-Free Synthesis of Sulfonyl- and Bromo-Substituted Indolo[2,1-α]isoquinoline Derivatives through Electrochemical Radical Cascade Cyclization Z.-J. Shen, B. Huang, N. Ma, L. Yao, C. Yang,* L. Guo and W. Xia* Adv. Synth. Catal. 2021, 363, 1944\r
\r
Photoinduced [3+2] Annulation of Alkene with o-Iodoanilines: An Expedient Approach to Indolines X. Zhao, L. Guo, C. Yang and W. Xia* Synthesis 2021, 53, 1341\r
\r
α-Selective Ring-Opening Reactions of Bicyclo[1.1.0]butyl Boronic Ester with Nucleophiles L. Guo, A. Noble, and V. K. Aggarwal* Angew. Chem. Int. Ed. 2021, 60, 212\r
\r
Visible-Light-Induced Palladium-Catalyzed Intermolecular Narasaka–Heck Reaction at Room Temperature L. Feng, L. Guo, C. Yang, J. Zhou,* and W. Xia* Org. Lett. 2020, 22, 3964\r
\r
Hydride Transfer Enables the Nickel-catalyzed ipso-Borylation and Silylation of Aldehydes W. Srimontree, L. Guo and M. Rueping* Chem. Eur. J. 2020, 26, 423\r
\r
Photoinduced Deoxygenative Borylations of Aliphatic Alcohols J. Wu, R. M. Bar, L. Guo, A. Noble, and V. K. Aggarwal* Angew. Chem. Int. Ed. 2019, 58, 18830\r
\r
Nickel-Catalyzed Exo-Selective Hydroacylation/Suzuki Cross-Coupling Reaction S.-C. Lee, L. Guo, and M. Rueping* Chem. Commun. 2019, 55, 14984\r
\r
Nickel-catalyzed Suzuki–Miyaura cross-couplings of aldehydes L. Guo, W. Srimontree, C. Zhu, B. Maity, X. Liu, L. Cavallo,* and M. Rueping* Nat. Commun. 2019, 10, 1957\r
\r
Transition Metal-Catalyzed Decarbonylative Coupling Reactions – Concepts, Classifications and Applications L. Guo, and M. Rueping*, Chem. Eur. J. 2018, 24, 7794\r
\r
Cross-Coupling of Amides with Alkylboranes via Nickel-Catalyzed C–N Bond Cleavage X. Liu, C.-C. Hsiao, L. Guo, and M. Rueping*, Org. Lett. 2018, 20, 2976\r
\r
Decarbonylative Cross-Couplings: Nickel Catalyzed Functional Group Interconversion Strategies for the Construction of Complex Organic Molecules L. Guo, and M. Rueping*, Acc. Chem. Res. 2018, 51, 1185\r
\r
Ligand-Controlled Chemoselective C(acyl)-O bond vs. C(aryl)-C bond Activation of Aromatic Esters in Nickel Catalyzed C(sp2)-C(sp3) Cross-Couplings A. Chatupheeraphat, H.-H. Liao, W. Srimontree, L. Guo, Y. Minenkov, A. Poater, L. Cavallo,* and M. Rueping*, J. Am. Chem. Soc. 2018, 140, 3724\r
\r
Nickel-Catalyzed Decarbonylative Silylation, Boronation and Amination of Arylamides via A Deamidative Reaction Pathway S.-C. Lee, L. Guo, H. Yue, H.-H. Liao, and M. Rueping* Synlett 2017, 28, 2594\r
\r
Synthesis of Amidines from Amides using a Nickel Catalyzed Decarbonylative Amination via CO Extrusion Intramolecular Recombination Fragment Coupling X. Liu, H. Yue, J. Jia, L. Guo, and M. Rueping* Chem. Eur. J. 2017, 23, 11771\r
\r
Nickel-Catalyzed Synthesis of Primary Aryl and Heteroaryl Amines via C–O Bond Cleavage H. Yue, L. Guo, X. Liu and M. Rueping* Org. Lett. 2017, 19, 1788\r
\r
Selective Reductive Removal of Ester and Amide Groups from Arenes and Heteroarenes through Nickel-Catalyzed C–O and C–N Bond Activation H. Yue, L. Guo, S.-C. Lee, X. Liu and M. Rueping* Angew. Chem. Int. Ed. 2017, 56, 3972\r
\r
Catalytic Ester and Amide to Amine Interconversion: Nickel-Catalyzed Decarbonylative Amination of Esters and Amides by C–O and C–C Bond Activation H. Yue, L. Guo, H.-H. Liao, Y. Cai, C. Zhu and M. Rueping* Angew. Chem. Int. Ed. 2017, 56, 4282\r
\r
Nickel-Catalyzed Alkoxy-Alkyl Interconversion with Alkylborane Reagents through C–O Bond Activation of Aryl and Enol Ethers L. Guo, X. Liu, C. Baumann and M. Rueping* Angew. Chem. Int. Ed. 2016, 55, 15415\r
\r
Functional Group Interconversion: Decarbonylative Borylation of Esters for the Synthesis of Organoboronates L. Guo and M. Rueping* Chem. Eur. J. 2016, 22, 16787\r
\r
Decarbonylative Silylation of Esters by Combined Nickel and Copper Catalysis for the Synthesis of Arylsilanes and Heteroarylsilanes L. Guo, A. Chatupheeraphat and M. Rueping* Angew. Chem. Int. Ed. 2016, 55, 11810\r
\r
Nickel-Catalyzed Csp2–Csp3 Cross-Coupling via C–O Bond Activation L. Guo, C.-C. Hsiao, H. Yue, X. Liu and M. Rueping* ACS Catal. 2016, 6, 4438\r
\r
Lewis Acid Assisted Nickel-Catalyzed Cross-Coupling of Aryl Methyl Ethers by C–O Bond-Cleaving Alkylation: Prevention of Undesired β-Hydride Elimination X. Liu, C.-C. Hsiao, I. Kalvet, M. Leiendecker, L. Guo, F. Schoenebeck* and M. Rueping* Angew. Chem. Int. Ed. 2016, 55, 6093\r
\r
Nickel Catalyzed Dealkoxylative Csp2–Csp3 Cross Coupling Reactions – Stereospecific Synthesis of Allylsilanes from Enol Ethers L. Guo, M. Leiendecker, C.-C. Hsiao, C. Baumann and M. Rueping* Chem. Commun. 2015, 51, 1937\r
\r
Metal-Catalyzed Dealkoxylative Caryl–Csp3 Cross-Coupling – Replacement of Aromatic Methoxy Groups of Aryl Ethers by Employing a Functionalized Nucleophile M. Leiendecker, C.-C. Hsiao, L. Guo, N. Alandini and M. Rueping* Angew. Chem. Int. Ed. 2014, 53, 12912\r
\r
Visible Light-Mediated Oxidative Quenching Reaction to Electron-Rich Epoxides: Highly Regioselective Synthesis of α-Bromo (di)Ketones and Mechanism Study L. Guo, C. Yang, L. Zheng and W. Xia* Org. Biomol. Chem. 2013, 11, 5787\r
\r
Reactivity Insight into Reductive Coupling and Aldol Cyclization of Chalcones by Visible Light Photocatalysis G. Zhao, C. Yang, L. Guo, H. Sun, R. Lin and W. Xia* J. Org. Chem. 2012, 77, 6302\r
\r
Visible Light-Induced Oxidative Coupling Reaction: Easy Access to Mannich-Type Products G. Zhao, C. Yang, L. Guo, H. Sun, C. Chen and W. Xia* Chem. Commun. 2012, 48, 2337