个人简介

Kang Zhang, MD, PhD is the Professor of the Faculty of Medicine, Macau University of Science and Technology (MUST). Dr. Zhang obtained his M.D. with Magna Cum Laude honors from Harvard Medical School and MIT joint MD program and his PhD in genetics from Harvard University. He did his postdoctoral training also at Harvard. He completed his residency in ophthalmology at Johns Hopkins University and his retina surgery fellowship at University of Utah. He was a faculty member at Johns Hopkins University, Cleveland Clinic Foundation, University of Utah, and University of California San Diego. Among his honors include AAAS fellow, fellow of American Institute for Medical and Biological Engineering, memberships in Association of American Physicians and American Society of Clinical Investigation; Outstanding Achievement Award of Chinese Ophthalmological Society, Burroughs Wellcome Clinical Scientist Award in Translational Research; Lew R. Wasserman Merit Award and Senior Investigator Award from Research to PreventBlindness; Charles Schepens Award for Excellence in Retina Research; and Johns Hopkins Medical Institutions Clinician Scientist Award, the Ophthalmologist 100 Powerlist, American’s Top Ophthalmologists. Dr. Zhang has published over 200 peer-reviewed manuscripts in top peer-reviewed journals- covering a wide range of topics in genetics, epigenetics, stem cells, nano-engineering and 3D printing, clinical trials, and artificial intelligence. He has more than 26,000 citations and an hindex of 80. His discovery that HTRA1 is a major susceptibility gene for age-related macular degeneration is listed as one of “top-ten breakthroughs in 2006” in Science Magzine. Education and Training 2002-2003 FELLOW, University of Utah School of Medicine, Salt Lake City, UT, Vitreoretinal Diseases and Surgery1996-1999 RESIDENT, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD, Ophthalmology 1995-1996 INTERN, Presbyterian/St. Lukes Hospital, Denver, CO, Medicine 1991-1995 MD, Harvard University Medical School - M.I.T., Health Sciences and Technology, Cambridge, MA, Medicine 1985-1991 PhD, Harvard University, Cambridge, MA, Genetics 1980-1984 BS, Sichuan University, Sichuan, China, Biochemistry Academic History 2019.8-Present Professor and Faculty of Medicine, Macau University of Science and Technology, Macao 2008.7-2019.8 Staff Physician, Veteran Affairs San Diego Health System 2008.7-2019.7 Full professor with tenure, University of California San Diego 2002.3-2008.6 Assistant Professor, Associate Professor with tenure, University of Utah, Department of Ophthalmology/Visual Sciences2000.10-2002.2 Assistant Staff, Cleveland Clinic Foundation, Cole Eye Institute 1999.7-2000.9 Instructor, Johns Hopkins University, Wilmer Eye Institute Professional Experiences A.Full Time Positions2014 – 2019 Co-Director, Biomaterials and Tissue Engineering Center, Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA 2009 – 2013 Founding Director, Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 2006 – 2008 Associate Professor with tenure, University of Utah, Department of Ophthalmology and Visual Science, John Moran Eye Center, Salt Lake City, UT 2002 – 2006 Attending Staff Physician, Veteran's Administration Medical Center, Salt Lake City, UT 2002 -2006 Assistant Professor, University of Utah, Department of Ophthalmology and Visual Science, John Moran Eye Center, Salt Lake City, UT2000 -2002 Assistant staff, Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, OH 1999 -2000 Instructor, Johns Hopkins University, School of Medicine, Wilmer Eye Institute, Baltimore, MD B. Editorial Experience 2015-present co-Editor in Chief, Signal Transduction and Targeted Therapy2018-present co-Editor in Chief, Precision Clinical Medicine 2013-present Associate Editor, Current Molecular Medicine 2013-present Editorial board, Journal of Biological Chemistry 2012-present Consulting Editor, Journal of Clinical Investigation 2012-present Associated Editor-in –Chief, Chinese Journal of Retinal Diseases 2006-2010 Chief Medical Editor, Ophthalmology News and World Report, China Edition. (circulation: 40,000+ ophthalmologists in Asia) C. Reviewer Experience Referee for American Journal of Human Genetics Referee for American Journal of Medical GeneticsReferee for American Journal of PathologyReferee for Archives of Ophthalmology Referee for Biochemical Journal Referee for BMC Genomics Referee for Cell Referee for Molecular CellReferee for Cell Stem Cell Referee for Developmental Dynamics Referee for Experimental Eye Research Referee for Expert Opinion in OphthalmologyReferee for Genome Biology Referee for Human Genetics Referee for Human Molecular GeneticsReferee for Human Gene Therapy Referee for International Journal of Biologic ScienceReferee for Investigative Ophthalmology and Visual Science Referee for Journal of Biological Chemistry Referee for Journal of Cataract and Refractive SurgeryReferee for Journal of Clinical InvestigationReferee for Journal of Lipid ResearchReferee for Journal of Medical GeneticsReferee for Journal of Neurology Referee for Lancet Referee for Molecular Therapy Referee for Molecular VisionReferee for Nature Referee for Nature Genetics Referee for Nature Medicine Referee for Nature MaterialsReferee for Nature Biomedical Engineering Referee for Nature Communications Referee for NeuroscienceReferee for New England Journal of MedicineReferee for Ophthalmic Genetics Referee for OphthalmologyReferee for PNAS Referee for PNAS Plus Referee for PLoS Biology Referee for PLoS Medicine Referee for PLoS GeneticsReferee for PLoS One Referee for Progress in Retina and EyeResearch Referee for Retina Referee for ScienceReferee for Science Translational Medicine Referee for Trend in Genetics Referee for Trend in Molecular Medicine Research Awards Prof. Zhang has been continousely funded by NIH and other foundations from 2000 to 2019.Administrative Experience A.Grant Review Committee/Study Section 2013-present Reviewer, New York Stem Cell Program 2010-present Reviewer, Medical Research Council UK 2010-present Reviewer, Wellcome Trust Research Programs UK 2013-present Reviewer, New York Stem Cell Program 2013- present Reviewer, Penn Stem Cell Program 2012-present Reviewer, Chinese Academy of Science Strategic Stem Cell Program 2009-present Reviewer, Natural Science foundation of China 2008-present Reviewer, ChangJiang Scholars Program, Ministry of Education, China 2009-present Reviewer Reviewer, National Basic Research Program, China 2007-present Ad Hoc Reviewer, Biology and Disease of the Posterior Eye Study Section (VISC), NIH 2006-present Ad Hoc Reviewer, Anterior Eye Disease Study Section (VISA), NIH 2007-present Distinguished Reviewer’s panel, National Eye Institute, NIH 2009-present Ad Hoc Reviewer, diabetic complications section, Juvenile Diabetes research Foundation 2006-Present Ad Hoc Reviewer, research grants and fellowships, Wellcome Trust, UK 2006-Present Ad Hoc Reviewer, research grants and fellowships, Medical Research Council, UK 2004-present Ad Hoc Reviewer, Neurobiology C Study Section, Medical Research Service, Department of Veterans Affairs Administration2002-present Ad Hoc Reviewer, research grants, Foundation Fighting Blindness, USA 2009-2010 ARRA grant panels 2007 Special emphasis panel, Gene environment Initiative, Nat Human Genome Research Institute, NIH 2007 CIDR Access Review Panel, National Human Genome Research Institute, NIH 2007 Ad Hoc Reviewer, research grants, Macular Disease Society, UK2003 Ad Hoc Reviewer, research grants, Foundation Fighting Blindness, Canada 2001 Ad Hoc Reviwer, postdoctoral training grant, Research into Aging, UK2000 Ad Hoc Reviewer, Medical Research Service, Department of Veterans Affairs Administration B. Professional Community Activities 2016 Co-organizer. Nature Conference on Tissue Engineering and Regenerative Medicine. Guangzhou, China 2016 Co-organizer, Nature Conference. Nuclear Reprogramming and the Cancer Genome. La Jolla, CA 2015 Co-organizer, Nature Conference. Epigenetics of Cancer and Aging, Beijing, China 2015 Co-organizer, International Congress of Ocular Cell and Stem Cell Biology 2014 Co-organizer, Nature Conference. Genomics and Stem Cell Based Therapies: Shaping the Future of Personalized Medicine, Guangzhou, China 2014 Co-organizer, Nature Conference. Genomic Technologies and Biomaterial for Understanding Disease, San Diego, CA 2014 Co-organizer, International Masters of Retina 2014 Co-organizer, Nature-Biocon Symposium 2014 Co-organizer, Nature-China Symposium 2012-pres Member, Harvard Medical School Dean’s Advisory Council. 2011-2013 Founding President, American Chinese Association for Research in Vision and Ophthalmology 2002-pres Medical Advisory Board, Genentech 2012-pres Medical Advisory Board, Thrombogenics 2008-pres Scientific Advisory Board, Lifeboat Foundation 2006-pres Scientific Advisory Board, Acucela 2010-pres co-organizer, International Masters of Retina 2011-pres Program Committee, Annual Meeting of Chinese Ophthalmological Society2012 Organizer, the Second World Wide Chinese Ophthalmologist Retina Summit 2012 Co-organizer, Nature-UCSD Institute for Genomic Medicine Symposium2010 Organizer, Genetics of Diabetic Retinopathy Workshop, San Diego, CA 2009 Retina Subspecialty Day, Moderator, AAO Annual Meeting 2009 Organizer, Shanghai International Ophthalmology Symposium 2006 Co-Organizer, Genetics of Diabetic Retinopathy Workshop, Salk Lake City, UT 2008 Organizer, Genetics of Diabetic Retinopathy Workshop, Salk Lake City, UT 2007 Organizing Committee member, International Forum of Vitreoretinal Diseases and Surgery, China 2007 Section Chair, Animal Model of Age-Related macular Degeneration. PreARVO Meeting 2007 on Retinal Degeneration and gene Therapy, FL 2007 Organizer, Shanghai International Ophthalmology Symposium 2006 Organizer, “Snowbird Neuroscience Symposium2006” 2005 Co-organizer, “Genetics of Molecular Biology of Retinal Diseases”, ancillary meeting of Annual Meeting of American Society of Human Genetics, UT. 1993-94 President, Harvard Chinese Student Association C. University Community Activities i.) College Level 2009-2013 Founding Director, Institute of Genomic Medicine, UCSD2008-2012 Member, MD-PhD Program Admissions Committee, UCSD/Salk/Burnham 2010-2012 Faculty Advisor, the MSTP Physician Scientist Colloquium 2009-2013 Member, Executive Committee, Research Council, UCSD Health Sciences 2008-2013 Member, Research Council, UCSD Health Science 2005 - 2008 Member, SOM Academic Senate Nominating Committee, Elected appointment by the Dean, University of Utah 2007-2008 Member, SOM Admissions Committee, University of Utah 2008-2007-2008 Member, MD-PhD program Admissions Committee, University of Utah ii.) Other Internal Level 2001 -2002 Member, Cleveland Clinic Foundation, Search Committee for the Director for the Center for Human Genetics and Genomics 1991 -1995 Member, Harvard University - M.I.T., M.D. Curriculum Committee, Division of Health Sciences and Technology1988 -1989 President, Harvard University, Chinese Student AssociationTeaching Responsibilities/Assignments A. Course Lectures 2015-2019 MSII Ophthalmology Skills Lab 2015 Retina OKAP Academic Lectures “Macular Dystrophy” 2015 Guest lecturer, Bioengineering Seminar 2015 Stein Grand Rounds/Geriatric Multi-Professional Lecture Series2014-2019 Guest lecturer, Molecular Basis of Human Disease (BIMM110) 2014-2019 Guest lecturer, “Genetics of Age Related Diseases” (PATH255/BIOM277) 2014 Guest Lecturer, PATH277 2014 Instructor, “Inherited Ocular Disorders” (Fellows’ Medical Genetics Course)2008-2012 Instructor, BMS core curriculum, quantitative Methods in Genetics (BIOM262) 2009 – 2010 Small group discussion leader, Genetics in Medicine, preclinical core curriculum, School of Medicine, UCSD2008 – 2009 Course Co-Director, Genetics in Medicine, preclinical core curriculum, School of Medicine, UCSD2008-2009 Core course in Cellular and Molecular Medicine, Biomedical Science PhD Program, UCSD 2008-pres Pharmacogenomics, School of Pharmacy and Pharmaceutical Sciences, UCSD 2008-pres Resident Lecture Series, Shiley Eye Center, UCSD2008-pres Co-Director, bi-monthly San Diego city-wide Retinal Fluorescein Angiogram Conference 2008-pres Visiting Professor, Peking University, China 2007-pres Visiting Professor, Fudan University, China 2006-pres Visiting Professor, Sichuan Academy of Medical Sciences, China 2005-2008 Frontiers in Neuroscience, PhD Program in Neuroscience, University of Utah, Salt Lake City, UT; contributing lecturer2005 Visiting Professor, King Khaled Eye Specialty Hospital. Riyahd, Saudi Arabia 2004 Faculty Research Topic Lecture Series, PhD. Program in Molecular Biology, University of Utah, Salt Lake City, UT; contributing lecturer 2003 – Pres Visiting Professor, Peking University Eye Center, Peking University, China 2003 - Pres Visiting Professor, Sichuan University, China 2003 - Pres Visiting Professor, Sichuan academy of Medical Sciences and Sichuan Provincial Hospital, China 2003 - Pres Visiting Professor, Zhong Shan Ophthalmic Center, Sun Yet-sen University, China 2002 - 2008 Director, Fluorescein Angiogram Conference, John Moran Eye Center, University of Utah, Salt Lake City, UT; Contributing lecturer 2002 - 2008 Grand Rounds, John Moran Eye Center, University of Utah, Salt Lake City, UT; Contributing lecturer2002 - 2008 Ophthalmology Resident Lectures - Lecture Series on the Retina, John Moran Eye Center, University of Utah, Salt Lake City, UT; Contributing lecturer 2000 -2002 Grand Rounds Quiz for residents, Cole Eye Institute, Cleveland Clinic 1992 -1994 Teaching Assistant in HMS-M.I.T. HST Genetics and Medicine, 80 students (MIT undergraduate and graduate students, Harvard Medical Students)

研究领域

Genetics, epigenetics, stem cells, and artificial intelligence

近期论文

1.Zhang K, Chaillet JR, Perkins LA, Halazonetis TD, Perrimon N. (1990) Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proc Natl Acad Sci U S A, 87(16), 6281-5.2. Zhang K, Smouse D, Perrimon N. (1991) The crooked neck gene of Drosophila contains a motif found in a family of yeast cell cycle genes. Genes Dev, 5(6), 1080-91. 3. Rutledge BJ*, Zhang K*, Bier E, Jan YN, Perrimon N. (1992) The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev, 6(8), 1503-17. *co-first authors. 4. Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA, Figueroa DJ, Austin CP, Gould RJ, Ayyagari R, Petrukhin K. (2001) A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nature Genet, 27(1), 89-93. 5. Yang Z, Peachey NS, Moshfeghi DM, Thirumalaichary S, Chorich L, Shugart YY, Fan K, Zhang K. (2002) Mutations in the RPGR gene cause X-linked cone dystrophy. Hum Mol Genet, 11(5), 605-11. 6. Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF. (2004) Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Am J Hum Genet, 74(4), 721-30.7.Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell, 116(6), 883-95. 8. Karan G, Lillo C, Yang Z, Cameron DJ, Locke KG, Zhao Y, Thirumalaichary S, Li C, Birch DG, Vollmer-Snarr HR, Williams DS, Zhang K. (2005) Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration. Proc Natl Acad Sci U S A, 102(11), 4164-9. 9. Magnusson KP*, Duan S, Sigurdsson H, Petursson H, Yang Z, Zhao Y, Bernstein PS, Ge J, Jonasson F, Stefansson E, Helgadottir G, Zabriskie NA, Jonsson T, Bjornsson A, Thorlacius T, Jonsson PV, Thorleifsson G, Kong A, Stefansson H, Zhang K*, Stefansson K, Gulcher JR*. (2006) CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med, 3(1), 109-114. *Co-corresponding authors.10. Brown DM, Kaiser PK, Michels M, Goubrane MD, Heier, JS, Kim RY, Sy JP, Schneider S for the ANCHOR Study Group. (2006) Ranibizumab versus Vertiporfin for Neovascular Age-Related Macular Degeneration. New Eng J of Med, 355(14): 1432-1444. 11. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY for the MARINA Study Group. (2006) Ranibizumab for Neovascular AgeRelated Macular Degeneration, New Eng J of Med, 355(14): 1419-1431. 12. Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K. (2006) A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science, 314(5801), 992-3. (see Science New Focus, same issue; Science Breakthoughs of the Year, 2006) 13. Kleiman M E, Yamada K, Kakeda A, Chandrasekaran V, Nozaki M, Baffi J Z, Albuquerque R J C, Yamasake S, Itaya M, Pan Y, Appukuttan B, Gibbs D, Yang Z, Kariko K, Ambati B, Wilgus T A, DiPietro L A, Sakurai E, Zhang K, Smith T R, Taylor E W, Ambati J. (2008). Sequence- and target-independent suppression of angiogenesis by siRNA via TLR3. Nature 452, 591-597. 14. Jones, CA, London, NR, Chen, H, Park, KW, Sauvaget, D, Rebecca A. Stockton, RA., Wythe, J. D., Suh, W, Larrieu-Lahargue, F, Mukouyama, Y, Lindblom, P, Seth, P, Frias, A, Nishiya, N, Ginsberg, M, Gerhardt, H, Zhang, K*, and Li, D.Y.* (2008). Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nature Medicine 14, 448-453. *co-corresponding authors. 15. Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Zeng J, Yang X, Ma X, Harmon J, Pearson E, Beuhler J, Luo L, Hau VS, Kaminoh Y, Zabriskie NA, Sun JK, Prakash M, Haman R, Tonna S, Constantine R, Ronquillo CC, Sadda SV, Avery RL, Brand JM, London N, King GL, Bernstein PS, Watkins S, Genetics of Diabetes and Diabetic Complication Study Group, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K. (2008). Promoter polymorphism of the Erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci. 105:6998-7003. Epub 2008 May 5. 16.Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS, Zhang K. (2008). Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. Journal Clinical Investigation 118:2908-2916.17. Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton DR, Klein ML, Hamon SC, Simmons E, Yu B, Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J, Zhang K. (2008). Tolllike receptor 3 and geographic atrophy in age-related macular degeneration. New England Journal of Med.14:1456-63. Epub 2008 Aug 27. 18. Jiao X, Yang Z, Yang X, Chen Y, Tong Z, Zhao C, Zeng J, Chen H, Gibbs D, Sun X, Li B, Wakins WS, Meyer C, Wang X, Kasuga D, Bedell M, Pearson E, Weinreb RN, Leske MC, Hennis A, DeWan A, Nemesure B, Jorde LB, Hoh J, Hejtmancik JF, Zhang K. (2009). Common variants on chromosome 2 and risk of primary open-angle glaucoma in the Afro-Caribbean population of Barbados. Proc Natl Acad Sci U S A. 106:17105-10. Epub 2009 Sep 24. 19. Yang Z, Tong Z, Chen Y, Zeng J, Lu F, Sun X, Zhao C, Wang K, Davey L, Chen H, London N, Muramatsu D, Salasar F, Carmona R, Kasuga D, Wang X, Bedell M, Dixie M, Zhao P, Yang R, Gibbs D, Liu X, Li Y, Li C, Li Y, Campochiaro B, Constantine R, Zack DJ, Campochiaro P, Fu Y, Li DY, Katsanis N, Zhang K. (2010). Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet. 6(2):e1000836. 20. Zhu, S, Li, W., Zhou, H., Wei, W., Ambasudhan, R., Lin, T., Kim, J., Zhang, K., Ding, S. (2010). Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds. Cell Stem Cells 7: 651-65521. Zhang,K*, Hopkins, JJ, Heier, JS, Birch, DG, Halperin, LS, Albini, TA, Brown, DM, Jaffe, GJ, Tao, W, and Williams, GA. (2011). Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration. PNAS 108(15):6241-5. *corresponding author. 22. Korn BS, Zhang K. . Carotid-cavernous sinus fistula. N Engl J Med. 2011 Feb 24;364(8): 23. Kim J, Efe JA, Zhu S, Talantova M, Yuan X, Wang S, Lipton SA, Zhang K, Ding S. (2011). Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A. 108:7838-43. 24. Li W, Sun W, Zhang Y, Wei W, Ambasudhan R, Xia P, Talantova M, Lin T, Kim J, Wang X, Kim WR, Lipton SA, Zhang K*, Ding S*. (2011) Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A. 108:8299-304. *co-corresponding author.25. Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. (2011). Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature 480:372-375. 26. Shaw P, Zhang L, Zhang M, Du H, Zhao L, Lee C, Grob S, Lim SL, Hughes G, Lee J, Bedell M, Nelson MH, Lu F, Krupa M, Luo J, Ouyang H, Tu Z, Su Zhiguang, Zhu J, Wei X, Feng Z, Duan Y, Yang Z, Ferreyra H, Bartsch DU, Kozak I, Zhang L, Lin F, Sun H, Feng H, Zhang K. (2012). Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. PNAS 109:13757-13762.27. Fang RH, Chen KN, Aryal S, Hu CM, Zhang K, Zhang L. (2012). Large-scale synthesis of lipid-polymer hybrid nanoparticles using a multi-inlet vortex reactor. Langmuir. 39:13824-9.28. Zhao J, Sun W, Cho HM, Ouyang H, Li W, Lin Y, Do J, Zhang L, Ding S, Liu Y, Lu P, Zhang K. (2013). Integration and long distance axonal regeneration in CNS from transplanted primitive neural stem cells. J Biol Chem. 288(1):164-8. 29. Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, Klotzle B, Bibikova M, Fan JB, Gao Y, Deconde R, Chen M, Rajapakse I, Friend S, Ideker T, Zhang K. (2013). Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates. Mol Cell, 49:359-67.30. Xue, Y-C., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., Jiang, L., Cai, Z., Sun, H., Zhang, K., Zhang, Y., Chen, J., and Fu, X-D. (2012) Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell 152:82-96.31. Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. (2013). JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 110:2377-82.32. Hu CM, Fang RH, Luk BT, Chen KN, Carpenter C, Gao W, Zhang K, Zhang L. (2013). 'Marker-of-self' functionalization of nanoscale particles through a top-down cellular membrane coating approach. Nanoscale. 5(7):2664-8. 33. X. Qu, W. Zhu, S. Huang, J. Y. Li, S. Chien, K. Zhang, S.C. Chen, (2013). Relative impact of uniaxial alignment vs. form-induced stress on differentiation of human adipose derived stem cells. Biomaterials, 11:9812-9818. 34. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K*, Guan KL*. (2014). Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 25:822-30. 35. Liao C, Yin, A, Peng CF, Fu F, Yang JX, Li R, Chen YY, Luo DH, Zhang YL, Ou YM, Li J, Wu J, Mai MQ, Hou R, Wu F, Luo H, Li DZ, Liu, HL, Zhang XZ, Zhang K. (2014). Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing, PNAS, 111:7415-20.36. Ouyang, H, Xue, Y, Lin, Y, Zhang, X, Xi, L, Patel, S, Gen Li, Jing Luo, Wei Jiang, Yang Y, Li, H, Zhang, M, Cai, G, Yeh, E, Pei, M, Cao, G, Zhang, L, Yu, B, Chen, S, Fu, XD, Liu, Y, Zhang K. (2014). WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature 511:358-61. 37.Copp JA, Fang RH, Luk BT, Hu CM, Gao W, Zhang K, Zhang L. (2014). Clearance of pathological antibodies using biomimetic nanoparticles. Proc Natl Acad Sci U S A. 111:13481-6. 38. Bhisitkul RB, Mendes TS, Rofagha S, Enanoria W, Boyer DS, Sadda SR, Zhang K. Macular Atrophy Progression and 7-Year Vision Outcomes in Subjects From the ANCHOR, MARINA, and HORIZON Studies: the SEVEN-UP Study. (2015). Am J Ophthalmol. 159:915-924.39. Zhao L, Chen, XJ, Zhu, J, Xi, YB, Yang, X, Hu, LD, Ouyang, H, Patel, SH, Jin, X, Lin, D, Wu, F, Flagg, K, Cai H, Li, G, Cao, G, Lin, Y, Chen, D, Wen, C, Chung, C, Wang, YD, Qiu, A, Yeh, E, Wang, W, Hu, X, Grob, S, Abagyan, R, Su, Z, Tjondro, HC, Zhao, XJ, Luo, H, Rui Hou, R, Perry, JP, Gao, W, Kozak, I, Granet, D, Li, Y, Sun, XD, Wang, J, Zhang, L, Liu, Y, Yan, YB, and Zhang, K. (2015). Lanosterol reverses protein aggregation in cataract. Nature 523:607-11 40. Hu, CM, Fang, RH, Wang, KC, Luk, BT, Thamphiwatana, S, Dehaini, D, Nguyen, P, Angsantikul, P, Wen, CH, Kroll, AV, Carpenter, C, Ramesh, M, Qu, V, Patel, S, Zhu, J, Hofman, FM, Chen, TC, Gao, W, Zhang, K*, Chien, S*, Liangfang Zhang, L* (2015). Nanoparticle biointerfacing via platelet membrane cloaking. Nature, 1;526(7571):118-21. *co-corresponding authors. 41. 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