个人简介

EducationPhD Michigan State UniversityBS Michigan State UniversityAcademic and Professional Experience2014-present Senior Instructor, Faculty of Health Sciences, University of Macau2008-2014 Research Scientist, Stem Cell Institute, UConn Health Center2003-2008 Post-doctoral Fellow, UConn Health CenterCourse OutlinesHSCI2003 Microbiology LabHSCI4002 Stem Cell Biology and Regenerative MedicineGEST1002 Quantitative Reasoning for Social ScienceGEST2001 Biology in Our Daily Life

研究领域

Molecular circuitry of induced Pluripotent Stem Cells (iPSC) reprogrammingMolecular mechanisms for Marfan Syndrome (MS), a genetic disease manifested in defects of mesenchymal lineages and connective tissuesRegulatory mechanisms by which human Embryonic Stem Cells (hESCs) differentiate into Mesenchymal Stem Cells (MSCs)Post-transcriptional regulations in hESC/iPSC self-renewal and differentiation

近期论文

Representative PublicationsLi E., Zhang Z., Jiang B., Yan L., Park J.W., and Xu R.H. Generation of mesenchymal stem cells from human embryonic stem cells in a complete serum-free condition. Int. J. Biol. Sci. 14(13):1901-9, 2018Yang J., Park J.W., Zheng D., and Xu R.H. Universal corneal epithelial-like cells derived from human embryonic stem cells for cellularization of a corneal scaffold. Trans’l Vision Sci. & Technol. 7(5):23, 2018Yan L., Jiang B., Li E.Q., Wang X.Y., Ling Q., Zheng D.J., Park J.W., Chen X., Cheung E., Du X., Li Y.C., Cheng G., He E.X., Xu R.H. Scalable Generation of Mesenchymal Stem Cells from Human Embryonic Stem Cells in 3D. Int. J. Biol. Sci. 14(10):1196-1210, 2018Park J.W.#, Yang J., Xu R.H. PAX6 alternative splicing and corneal development. Stem Cells and Development. 27(6):367-377, 2018Park J.W., Yan L., Stoddard C., Wang X.F., Yue Z.C., Crandall L., Robinson T., Chang Y.X., Denton K., Li E.Q., Jiang B., Zhang Z.W., Martins-Taylor K., Yee S.P., Yue L.X., Xu, R.H., Recapitulating and correcting Marfan Syndrome in a cellular model. Int. J. Biol. Sci. 13(5):588-603, 2017Wang J.*, Park J.W.*, Drissi H., Wang X., and Xu R.H. Epigenetic Regulation of miR-302 by JMJD1C Inhibits Neural Differentiation of Human Embryonic Stem Cells. J. Biol. Chem. 289(4):2384-95, 2014Brooks A.N., Yang L., Duff M.O., Hansen K.D., Park J.W., Dudoit S., Brenner S.E., Graveley B.R. Conservation of an RNA Regulatory Map Between Drosophila and Mammals. Genome Research. 21(2):193-202, 2011Zeng H., Guo M., Martins-Taylor K., Wang X., Zhang Z., Park J.W., Zhan S., Kronenberg M.S., Lichtler A., Liu H.X., Chen F.P., Yue L., Li, X.J., Xu R.H. Specification of Region-specific Neurons Including Forebrain Glutamatergic Neurons From Human Induced Pluripotent Stem Cells. PLoS ONE. 5(7):e11853, 2010Zeng H., Park J.W., Guo M., Lin G., Li X., Chen F., Xu R.H. Lack of ABCG2 Expression and Side Population Properties in Human Pluripotent Stem Cells. Stem Cells. 27(10):2435-45, 2009Voss P.G., Gray R.M., Dickey S.W., Wang W., Park J.W., Kasai K.I., Hirabayashi, J., Patterson R.J., and Wang J.L. Dissociation of the carbohydrate-binding and splicing activities of galectin-1. Arch Biochem Biophys. 478(1):18-25. Epub, 2008.Olson S., Blanchette M., Park J.W., Savva Y., Yeo G., Yeakley J., Rio D., and Graveley B.R. A regulator of Dscam mutually exclusive splicing fidelity. Nature Struct and Mol Biol. 14:1134 – 1140, 2007Yang L., Park J.W., and Graveley B.R. Splicing from the outside in. Molecular Cell. 27:861-2, 2007Park J.W. and Graveley B.R. Complex alternative splicing. In Alternative splicing in the postgenomic era. edited by Graveley B.R. and Blencowe B. Eurekah Biosciences. 623:50-63, 2007Wang W.*, Park J.W.*, Wang J.L., and Patterson R.J. Immunoprecipitation of spliceosomal RNAs by antisera to galectin1-1 and galectins-3 (*equal contribution). Nucleic Acids Res. 34:5166-74, 2006Park J.W. and Graveley, B.R. The use of RNA interference to dissect the roles of trans-acting factors in alternative pre-mRNA splicing. Methods. 37:341-4, 2005Philips D.L., Park J.W. and Graveley B.R. A computational and experimental approach towards a priori identification of alternatively spliced exons. RNA. 10:1838-1844, 2004Park J.W., Parisky K., Celotto A., Reenan R.A., and Graveley B.R. Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci USA. 101:15974-15979, 2004Park J.W., Voss P., Grabski S., Wang J.L., and Patterson R.J. Association of galectins-1 and galectins-3 with Gemin4 in complexes containing the SMN protein. Nucleic Acids Res. 27(17):3595-3602, 2001Patterson R.J., Park J.W., and Wang J.L. Intracellular functions of galectins. Recent Res. Dev. Mol. Cell. Biol. 2:233-245, 2001