个人简介

EducationPhD Department of Genetics, The University of Melbourne, Australia (2007)BSc (1st Class Hons) Department of Genetics, The University of Melbourne, Australia (2002)BSc Faculty of Science, The University of Melbourne, Australia (2001)Diploma Biotechnology, Ngee Ann Polytechnic, Singapore (1999)Academic and Professional Experience2013-present Assistant Professor, Faculty of Health Sciences, University of Macau2008-2013 Postdoctoral Research Fellow, Department of Biochemistry and Molecular Pharmacology, Harvard Medical School, USA2007-2008 Postdoctoral Research Fellow, Department of Genetics, The University of Melbourne, AustraliaCourse OutlinesHSCI2004 Genetics and EpigeneticsGEST1007 Fun in Health Science

研究领域

To understand how pathogenic fungi cause diseases in humans.To understand how transcription is regulated.

近期论文

Representative PublicationsJournal PublicationChoi, G.C.G., Zhou, P., Yuen, C.T.L., Chan, B.K.C., Xu, F., Bao, S., Chu, H.Y., Thean, D., Tan, K., Wong, K.H., Zheng, Z., Wong, A.S.L. “Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9” Nature Methods 2019.https://www.nature.com/articles/s41592-019-0473-0Petrenko, N. *, Jin, Y. *, Dong, L., Wong, K.H. *# and Struhl, K#. “Requirements for RNA polymerase II preinitiation complex formation in vivo.” eLife 2019; 8:e43654. (* Equal contribution; # Corresponding author)https://doi.org/10.7554/eLife.43654Kim, S.H., Iyer, K.R., Pardeshi, L., Munoz, J.F., Robbins, N., Cuomo, C.A., Wong, K.H., Cowen, L.E. “Genetic analysis of Candida auris implicates Hsp90 in morphogenesis and Azole tolerance and Cdr1 in Azole resistance.” MBio 2019; 10(1). pII:e02529-18.https://mbio.asm.org/content/10/1/e02529-18Vassiliadis, D., Wong, K.H., Andrianopoulos, A., Monahan, B.J. “A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe.” BMC Genomics 2019; 20(1):251.https://doi.org/10.1186/s12864-019-5602-8Qin, L., Li, A., Tan, K., Guo, S., Chen, Y., Wang, F., and Wong, K.H. “Universal plasmids to facilitate gene deletion and gene tagging in filamentous fungi.” Fungal Genetics and Biology 2019; 125:28-35.https://doi.org/10.1016/j.fgb.2019.01.004Tan, K., and Wong, K.H. “RNA polymerase II ChIP-seq—a powerful and highly affordable method for studying fungal genomics and physiology.” Biophysical Reviewshttps://rdcu.be/bf1ibZhang, B., Lyu, J., Liu, Y., Wu, C., Yang, E.J., Pardeshi, L., Tan, K., Wong, K.H., Chen, Q., Xu, X., Deng C. and Shim, J.S. “BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition.” Oncogene 2018; 37:6341-6356.https://doi.org/10.1038/s41388-018-0408-8