个人简历
Education Experience 2001-2006 Ph. D. Chemistry Brisbane, Australia 1997-2000 B.Sc. Chemistry and Biochemistry Victoria University of Wellington, NZ Professional Experience 2006-2007 Postdoctoral Researcher UC San Diego, USA 2007-2010 Postdoctoral Researcher University College Dublin, Ireland 2011-2015 Postdoctoral Researcher University of Hawai’i at Hilo, USA
研究领域
Research in the Clark group focuses on microbial natural products as applied to drug discovery, metabolomics, and chemical ecology. Microbes have long been a source of potent antimicrobial and anticancer agents, and we have a particular interest in marine and extremophilic microbes as a source of new drug leads. We also investigate chemical ecology: what role the metabolites serve for the microbe itself, and how are they involved in the interaction of microbes with other organisms. The group uses metabolic profiling and multivariate statistical techniques in all of these research avenues in order to classify samples, identify active components, and elucidate the interactions of molecules and organisms. While microbes are the primary focus of the group we also have experience working with plants and marine organisms if there are particularly interesting ecological questions to be addressed in these areas.
近期论文
2018 Chemical and genetic differences between Hawaiian lineages of the alga Asparagopsis taxiformis Clark, Benjamin R.; Mizobe, Mindy; Kaluhiwa, Jerry L. M.; et al. Journal of Applied Phycology 30 2015 Unusual Flavonoid Glycosides from the Hawaiian Tree Metrosideros polymorpha Clark, Benjamin R.; Pramanick, Swapan; Arancon, Norman; et al. Natural Product Communications 10 2014 Chemotaxonomy of Hawaiian Anthurium Cultivars Based on Multivariate Analysis of Phenolic Metabolites Clark, Benjamin R.; Bliss, Barbara J.; Suzuki, Jon Y.; et al. Journal of Agricultural and Food Chemistry 62 2014 Enzymatic halogenation in stereoselective synthesis Murphy, Cormac D.; Clark, Benjamin R. Stereoselective Synthesis of Drugs and Natural Products 2 2012 Flavone C-glycosides from Anthurium andraeanum Clark, Benjamin R.; Suzuki, Jon Y.; Bliss, Barbara J.; et al. Natural Product Communications 7 2012 Production of the novel lipopeptide antibiotic trifluorosurfactin via precursor-directed biosynthesis O’Connor, Neil K.; Rai, Dilip K.; Clark, Benjamin R.; et al. Journal of Fluorine Chemistry 143 2011 Bacterial production of hydroxylated and amidated metabolites of flurbiprofen Bright, Tara V.; Clark, Benjamin R.; O’Brien, Eimear; et al. Journal of Molecular Catalysis B-Enzymatic 72 2011 Biodegradation of polyfluorinated biphenyl in bacteria Hughes, David; Clark, Benjamin R.; Murphy, Cormac D. Biodegradation 22 2011 Production of anticancer polyenes through precursor-directed biosynthesis Clark, Benjamin R.; O’Connor, Stephen; Fox, Deirdre; et al. Organic & Biomolecular Chemistry 9 2011 Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses Udwary, Daniel W.; Gontang, Erin A.; Jones, Adam C.; et al. Applied and Environmental Microbiology 77 2011 Structures and Biosynthesis of the Pyridinopyrones, Polyenepyrones from a Marine-Derived Streptomyces Species Fukuda, Takashi; Miller, Eric D.; Clark, Benjamin R.; et al. Journal of Natural Products 74 2010 The natural products chemistry of cyanobacteria Tidgewell, Kevin; Clark, Benjamin R.; Gerwick, William H. Natural Products Structural Diversity-II Secondary Metabolites: Sources, Structures and Chemical Biology 2 2009 Antimalarial Peptides from Marine Cyanobacteria: Isolation and Structural Elucidation of Gallinamide A Linington, Roger G.; Clark, Benjamin R.; Trimble, Erin E.; et al. Journal of Natural Products 72 2009 Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum Clark, Benjamin R.; Murphy, Cormac D. Organic & Biomolecular Chemistry 7 2009 Metabolism of fluoroorganic compounds in microorganisms: impacts for the environment and the production of fine chemicals Murphy, Cormac D.; Clark, Benjamin R.; Amadio, Jessica Applied Microbiology and Biotechnology 84 2009 Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp. Moran, Stephen; Rai, Dilip K.; Clark, Benjamin R.; et al. Organic & Biomolecular Chemistry 7 2008 Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages Simmons, T. Luke; Coates, R. Cameron; Clark, Benjamin R.; et al. Proceedings of the National Academy of Sciences of the United States of America 105 2008 Natural products chemistry and taxonomy of the marine cyanobacterium Blennothrix cantharidosmum Clark, Benjamin R.; Engene, Niclas; Teasdale, Margaret E.; et al. Journal of Natural Products 71 2007 The effect of halide salts on the production of Gymnoascus reessii polyenylpyrroles Clark, Benjamin R.; Lacey, Ernest; Gill, Jennifer H.; et al. Journal of Natural Products 70 2006 Citrinin revisited: from monomers to dimers and beyond Clark, BR; Capon, RJ; Lacey, E; et al. Organic & Biomolecular Chemistry 4
