个人简历

1979-1983 江西大学生物系，生物学学士\r
1983-1986 江西大学生物系，动物学硕士\r
1988-1990 美国福特汉姆大学，细胞生物学硕士\r
1991-1996 美国爱因斯坦医学院，细胞生物学博士\r
1996-2000 美国霍华德·休斯医学研究所斯隆-凯特琳癌症中心，博士后\r
2000-2002 美国加州大学Riverside分校，Assistant Professor\r
2002-至今 清华大学生命科学学院，教授、博导

研究领域

"""""主要运用分子生物学、细胞生物学、生物信息学等多学科手段，通过类器官技术和小鼠模型等研究肠、胃等成体干细胞自我更新和分化的机制；同时探索TGF-β和Wnt信号调控细胞命运的分子机制及其相关疾病发生发展的机理。"

近期论文

Nong J, Kang K, Shi Q, Zhu X, Tao Q, Chen YG#. 2021 Phase separation of Axin organizes the β-catenin destruction complex. Journal of Cell Biology, 220(4):e202012112.\r
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Wang YL, Song WL, Wang JL, Wang T, Xiong XC, Qi Z, Fu W#, Yang XR#, Chen YG#. 2020 Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 217(2):e20191130.\r
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Li Y, Liu Y, Chiang YJ, Huang F, Li Y, Li X, Ning Y, Zhang W, Deng H, Chen YG#. 2019 DNA damage activates TGF-β signaling via ATM-c-Cbl-mediated stabilization of the type II receptor TβRII. Cell Reports, 28(3):735-745.e4.\r
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Huang F, Shi Q, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG#. 2018 HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in breast cancer. Cancer Research, 78(21):6073-6085.\r
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Qi Z, Li Y, Zhao B, Xu C, Liu Y, Wang X, Yang X, Li B, Han JD, Chen YG#. 2017 BMP restricts the self-renewal of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nature Communications, 8:13824.\r
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Zhao B, Qi Z, Li Y, Wang C, Fu W, Chen YG# 2015 The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells. Nature Communications, 6:7166.\r
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Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG# 2013 c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Molecular Cell, 49(3):499-510.\r
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Li Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG# 2012 BMP4 signaling acts via Dual Specificity Phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell, 10:171-182.\r
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Gao C, Cao W, Bao W, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG# 2010 Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nature Cell Biology, 12:781-790.\r
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Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X#, Chen YG# 2009 Single molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization. Proc Natl Acad Sci. USA, 106:15679-15683.\r
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Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG# 2008 MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.\r
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Zhang L, Zhou H, Su Y, Sun S, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG#, Meng A# 2004 Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117.