个人简历

邓务国，博士、教授、博士生导师。
主要从事肿瘤基因表达调控和信号转导、恶性肿瘤发病机制、肿瘤靶向治疗等方面的基础和转化研究，并取得了阶段性成果。近年来，作为课题负责人主持国家“863”项目、国家自然科学基金、国家博士点基金，国家重点实验室自主课题、美国NCISPORE等研究项目10余项。作为通讯作者或第一作者，在国际知名科学杂志Oncotarget,MolCancer,MolOncol,JPinealRes,Blood，CancerRes，JBiolChem等发表SCI论文70多篇。

近期论文

1.TangR,XuX,YangW,YuW,HouS,XuanY,TangZ,ZhaoS,ChenY,XiaoX,HuangW,GuoW,LiM,DengW*.MED27promotesmelanomagrowthbytargetingAKT/MAPKandNF-κB/iNOSsignalingpathways.CancerLett.2016Apr1;373(1):77-87.(IF:5.621)
2.XuanY,WangJ,BanL,LuJJ,YiC,LiZ,YuW,LiM,XuT,YangW,TangZ,TangR,XiaoX,MengS,ChenY,LiuQ,HuangW,GuoW,CuiX,DengW*.hnRNPA2/B1activatescyclooxygenase-2andpromotestumorgrowthinhumanlungcancers.MolOncol.2016Apr;10(4):610-24.(IF:5.331)
3.LuJJ,FuL,TangZ,ZhangC,QinL,WangJ,YuZ,ShiD,XiaoX,XieF,HuangW,DengW*.MelatonininhibitsAP-2β/hTERT,NF-κB/COX-2andAkt/ERKandactivatescaspase/CytoCsignalingtoenhancetheantitumoractivityofberberineinlungcancercells.Oncotarget.2016Jan19;7(3):2985-3001.(IF:6.359)
4.TangZ,YuW,ZhangC,ZhaoS,YuZ,XiaoX,TangR,XuanY,YangW,HaoJ,XuT,ZhangQ,HuangW,DengW*,GuoW*.CREB-bindingproteinregulateslungcancergrowthbytargetingMAPKandCPSF4signalingpathway.MolOncol.2016Feb;10(2):317-29.(IF:5.331)
5.TangYL,HuangLB,LinWH,WangLN,TianY,ShiD,WangJ,QinG,LiA,LiangYN,ZhouHJ,KeZY,HuangW,DengW*,LuoXQ.ButeininhibitscellproliferationandinducescellcyclearrestinacutelymphoblasticleukemiaviaFOXO3a/p27kip1pathway.Oncotarget.2016Feb23.doi:10.18632/oncotarget.7624.[Epubaheadofprint](IF:6.359)
6.QinL,TianY,YuZ,ShiD,WangJ,ZhangC,PengR,ChenX,LiuC,ChenY,HuangW,DengW*.TargetingPDK1withdichloroacetophenonetoinhibitacutemyeloidleukemia(AML)cellgrowth.Oncotarget.2016Jan12;7(2):1395-407.(IF:6.359)
7.QinG,XuF,QinT,ZhengQ,ShiD,XiaW,TianY,TangY,WangJ,XiaoX,DengW*,WangS*.Palbociclibinhibitsepithelial-mesenchymaltransitionandmetastasisinbreastcancerviac-Jun/COX-2signalingpathway.Oncotarget.2015Dec8;6(39):41794-808.(IF:6.359)
8.ZhangLN,GaoYH,LanXW,TangJ,SuZ,MaJ,DengW,OuYangPY,XieFY.Propensityscorematchinganalysisofcisplatin-basedconcurrentchemotherapyinlowrisknasopharyngealcarcinomaintheintensity-modulatedradiotherapyera.Oncotarget.2015Dec22;6(41):44019-29.(IF:6.359)
9.TianY,QinL,QiuH,ShiD,SunR,LiW,LiuT,WangJ,XuT,GuoW,KangT,HuangW,WangG,DengW*.RPS3regulatesmelanomacellgrowthandapoptosisbytargetingCytoC/Ca2+/MICU1dependentmitochondrialsignaling.Oncotarget.2015Oct6;6(30):29614-25.(IF:6.359)
10.QinY,ChenW,XiaoY,YuW,CaiX,DaiM,XuT,HuangW,GuoW,DengW,WuT.RFPL3andCBPsynergisticallyupregulatehTERTactivityandpromotelungcancergrowth.Oncotarget.2015Sep29;6(29):27130-45.(IF:6.359)
11.XiaoY,WangJ,QinY,XuanY,JiaY,HuW,YuW,DaiM,LiZ,YiC,ZhaoS,LiM,DuS,ChengW,XiaoX,ChenY,WuT,MengS,YuanY,LiuQ,HuangW,GuoW,WangS,DengW*.Ku80cooperateswithCBPtopromoteCOX-2expressionandtumorgrowth.Oncotarget.2015Apr10;6(10):8046-61.(IF:6.359)
12.ShiD,XiaoX,TianY,QinL,XieF,SunR,WangJ,LiW,LiuT,XiaoY,YuW,GuoW,XiongY,QiuH,KangT,HuangW,ZhaoC,DengW*.Activatingenhancer-bindingprotein-2αinducescyclooxygenase-2expressionandpromotesnasopharyngealcarcinomagrowth.Oncotarget.2015Mar10;6(7):5005-21.(IF:6.359)
13.DaiM,LuJJ,GuoW,YuW,WangQ,TangR,TangZ,XiaoY,LiZ,SunW,SunX,QinY,HuangW,DengW,WuT.BPTFpromotestumorgrowthandpredictspoorprognosisinlungadenocarcinomas.Oncotarget.2015Oct20;6(32):33878-92.(IF:6.359)
14.WangL,SangY,TangJ,ZhangRH,LuoD,ChenM,DengW,KangT.Down-regulationofprostatestemcellantigen(PSCA)bySlugpromotesmetastasisinnasopharyngealcarcinoma.JPathol.2015Dec;237(4):411-22.(IF:7.429)
15.HuK,LiaoD,WuW,HanAJ,ShiHJ,WangF,WangX,ZhongL,DuanT,WuY,CaoJ,TangJ,SangY,WangL,LvX,XuS,ZhangRH,DengWG,LiSP,ZengYX,KangT.Targetingtheanaphase-promotingcomplex/cyclosome(APC/C)-bromodomaincontaining7(BRD7)pathwayforhumanosteosarcoma.Oncotarget.2014May30;5(10):3088-100.(IF:6.359)
16.ChenW,LuJ,QinY,WangJ,TianY,ShiD,WangS,XiaoY,DaiM,LiuL,WeiG,WuT,JinB,XiaoX,KangTB,HuangW,DengW*.Retfingerprotein-like3promotestumorcellgrowthbyactivatingtelomerasereversetranscriptaseexpressioninhumanlungcancercells.Oncotarget.2014Dec15;5(23):11909-23.(IF:6.359)
17.GuoW,LuJ,DaiM,WuT,YuZ,WangJ,ChenW,ShiD,YuW,XiaoY,YiC,TangZ,XuT,XiaoX,YuanY,LiuQ,DuG,DengW*.TranscriptionalcoactivatorCBPupregulateshTERTexpressionandtumorgrowthandpredictspoorprognosisinhumanlungcancers.Oncotarget.2014Oct15;5(19):9349-61.(IF:6.359)
18.JinH,WangY,ZhouL,LiuL,ZhangP,DengW,YuanY.Melatoninattenuateshypoxicpulmonaryhypertensionbyinhibitingtheinflammationandtheproliferationofpulmonaryarterialsmoothmusclecells.JPinealRes.2014Nov;57(4):442-50.doi:10.1111/jpi.12184.Epub2014Oct14.(IF:9.6)
19.YuZ,GuoW,MaX,ZhangB,DongP,HuangL,WangX,WangC,HuoX,YuW,YiC,XiaoY,YangW,QinY,YuanY,MengS,LiuQ,DengW*.Gamabufotalin,abufadienolidecompoundfromtoadvenom,suppressesCOX-2expressionthroughtargetingIKKβ/NF-κBsignalingpathwayinlungcancercells.MolCancer.2014Aug31;13:203.(IF:5.397)
20.YiC,ZhangY,YuZ,XiaoY,WangJ,QiuH,YuW,TangR,YuanY,GuoW,DengW*.Melatoninenhancestheanti-tumoreffectoffisetinbyinhibitingCOX-2/iNOSandNF-κB/p300signalingpathways.PLoSOne.2014Jul7;9(7):e99943.(IF:3.234)
21.FuL,ShiK,WangJ,ChenW,ShiD,TianY,GuoW,YuW,XiaoX,KangT,WangS,HuangW,DengW*.TFAP2BoverexpressioncontributestotumorgrowthandapoorprognosisofhumanlungadenocarcinomathroughmodulationofERKandVEGF/PEDFsignaling.MolCancer.2014Apr26;13:89.(IF:5.397)
22.ChenW,QinL,WangS,LiM,ShiD,TianY,WangJ,FuL,LiZ,GuoW,YuW,YuanY,KangT,HuangW,DengW*.CPSF4activatestelomerasereversetranscriptaseandpredictspoorprognosisinhumanlungadenocarcinomas.MolOncol.2014May;8(3):704-16.(IF:5.935)
23.ShiD,XieF,ZhangY,TianY,ChenW,FuL,WangJ,GuoW,KangT,HuangW,DengW*.TFAP2AregulatesnasopharyngealcarcinomagrowthandsurvivalbytargetingHIF-1αsignalingpathway.CancerPrevRes.2014Feb;7(2):266-77.(IF:4.891)
24.WangJ,GuoW,ChenW,YuW,TianY,FuL,ShiD,TongB,XiaoX,HuangW,DengW*.Melatoninpotentiatestheantiproliferativeandpro-apoptoticeffectsofursolicacidincoloncancercellsbymodulatingmultiplesignalingpathways.JPinealRes.2013May;54(4):406-16.(IF:7.304).
25.GuoW,ChenW,YuW,HuangW,DengW*.SmallinterferingRNA-basedmoleculartherapyofcancers.ChinJCancer.2013Sep;32(9):488-93.(IF=2.155).
26.QinY,DengW,EkmekciogluS,GrimmEA.Identificationofuniquesensitizingtargetsforanti-inflammatoryCDDO-Meinmetastaticmelanomabyalarge-scalesyntheticlethalRNAiscreening.PigmentCellMelanomaRes.2013Jan;26(1):97-112.(IF:5.839).
27.ShiD,XiaoX,WangJ,LiuL,ChenW,FuL,XieF,HuangW,DengW*.Melatoninsuppressesproinflammatorymediatorsinlipopolysaccharide-stimulatedCRL1999cellsviatargetingMAPK,NF-κB,c/EBPβ,andp300signaling.JPinealRes.2012Sep;53(2):154-65.(IF:7.812).
28.WangJ,XiaoX,ZhangY,ShiD,ChenW,FuL,LiuL,XieF,KangT,HuangW,DengW*.SimultaneousmodulationofCOX-2,p300,Akt,andApaf-1signalingbymelatonintoinhibitproliferationandinduceapoptosisinbreastcancercells.JPinealRes.2012Aug;53(1):77-90.(IF:7.812).
29.TangQL,XieXB,WangJ,ChenQ,HanAJ,ZouCY,YinJQ,LiuDW,LiangY,ZhaoZQ,YongBC,ZhangRH,FengQS,DengWG,ZhuXF,ZhouBP,ZengYX,ShenJN,KangT.Glycogensynthasekinase-3β,NF-κBsignaling,andtumorigenesisofhumanosteosarcoma.JNatlCancerInst.2012May16;104(10):749-63.(IF:14.336).